Synthesis and Various Biological Properties of 3-(4-Benzylpiperizino)-1-(4-Ethoxyphenyl)-1-Alkyl(Aryl)-2-Phenylpropan-1-OL Dihydrochlorides
- Authors: Gevorgyan G.A.1, Gasparyan N.K.1, Papoyan O.A.1, Tumadzhyan A.E.1, Tatevosyan A.A.1, Panosyan G.A.1
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Affiliations:
- A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
- Issue: Vol 51, No 1 (2017)
- Pages: 30-34
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244499
- DOI: https://doi.org/10.1007/s11094-017-1552-0
- ID: 244499
Cite item
Abstract
Aminomethylation of 1-(4-ethoxyphenyl)-2-phenylethanone yielded 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one. Reduction of this compound with lithium aluminum hydride produced 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one, and interaction of this with Grignard reagents produced 3-(4-benzylpiperazinyl)-1-(4-ethoxyphenyl)-1-alkyl(aryl)-2-phenylpropan-1-ones. Some of the dihydrochlorides of the resulting compounds were found to have anti-inflammatory, analgesic, and peripheral n-cholinolytic activity.
About the authors
G. A. Gevorgyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Author for correspondence.
Email: gyulgev@gmail.com
Armenia, 26 Azatutyan Prospekt, Erevan, 0014
N. K. Gasparyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Azatutyan Prospekt, Erevan, 0014
O. A. Papoyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Azatutyan Prospekt, Erevan, 0014
A. E. Tumadzhyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Azatutyan Prospekt, Erevan, 0014
A. A. Tatevosyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Azatutyan Prospekt, Erevan, 0014
G. A. Panosyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Azatutyan Prospekt, Erevan, 0014