Synthesis and Various Biological Properties of 3-(4-Benzylpiperizino)-1-(4-Ethoxyphenyl)-1-Alkyl(Aryl)-2-Phenylpropan-1-OL Dihydrochlorides
- Autores: Gevorgyan G.1, Gasparyan N.1, Papoyan O.1, Tumadzhyan A.1, Tatevosyan A.1, Panosyan G.1
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Afiliações:
- A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
- Edição: Volume 51, Nº 1 (2017)
- Páginas: 30-34
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244499
- DOI: https://doi.org/10.1007/s11094-017-1552-0
- ID: 244499
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Resumo
Aminomethylation of 1-(4-ethoxyphenyl)-2-phenylethanone yielded 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one. Reduction of this compound with lithium aluminum hydride produced 3-(4-benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)-2-phenylpropan-1-one, and interaction of this with Grignard reagents produced 3-(4-benzylpiperazinyl)-1-(4-ethoxyphenyl)-1-alkyl(aryl)-2-phenylpropan-1-ones. Some of the dihydrochlorides of the resulting compounds were found to have anti-inflammatory, analgesic, and peripheral n-cholinolytic activity.
Sobre autores
G. Gevorgyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Autor responsável pela correspondência
Email: gyulgev@gmail.com
Armênia, 26 Azatutyan Prospekt, Erevan, 0014
N. Gasparyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armênia, 26 Azatutyan Prospekt, Erevan, 0014
O. Papoyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armênia, 26 Azatutyan Prospekt, Erevan, 0014
A. Tumadzhyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armênia, 26 Azatutyan Prospekt, Erevan, 0014
A. Tatevosyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armênia, 26 Azatutyan Prospekt, Erevan, 0014
G. Panosyan
A. L. Mndzhoyan Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: gyulgev@gmail.com
Armênia, 26 Azatutyan Prospekt, Erevan, 0014