Selection of Standardization Parameters and Development of Quality Control Methods for Isoleucyl-Tryptophan Dipeptide Coordination Complex with Iron(II) (Timofer)


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Abstract

The coordination complex of the dipeptide isoleucyl-tryptophan with Fe(II) possesses immunostimulating activity and is effective for treating iron- and immunodeficiency and pulmonary, rheumatological, and urological diseases. Results are presented from the development of quantitative assays for isoleucyl-tryptophan– Fe(II) using the Fe(II) ion and the tryptophan indole moiety. The standardization parameters of a reference sample, drug substance, and its dosage form are determined.

About the authors

N. D. Bunyatyan

I. M. Sechenov First Moscow State Medical University; State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 127051

B. M. Kholnazarov

State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, Moscow, 127051

Yu. V. Olefir

State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, Moscow, 127051

G. M. Bobizoda

State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, Moscow, 127051


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