Selection of Standardization Parameters and Development of Quality Control Methods for Isoleucyl-Tryptophan Dipeptide Coordination Complex with Iron(II) (Timofer)
- Authors: Bunyatyan N.D.1,2, Kholnazarov B.M.2, Olefir Y.V.2, Bobizoda G.M.2
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Affiliations:
- I. M. Sechenov First Moscow State Medical University
- State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- Issue: Vol 50, No 9 (2016)
- Pages: 620-624
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244449
- DOI: https://doi.org/10.1007/s11094-016-1502-2
- ID: 244449
Cite item
Abstract
The coordination complex of the dipeptide isoleucyl-tryptophan with Fe(II) possesses immunostimulating activity and is effective for treating iron- and immunodeficiency and pulmonary, rheumatological, and urological diseases. Results are presented from the development of quantitative assays for isoleucyl-tryptophan– Fe(II) using the Fe(II) ion and the tryptophan indole moiety. The standardization parameters of a reference sample, drug substance, and its dosage form are determined.
About the authors
N. D. Bunyatyan
I. M. Sechenov First Moscow State Medical University; State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 127051
B. M. Kholnazarov
State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 127051
Yu. V. Olefir
State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 127051
G. M. Bobizoda
State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 127051