Enviar artigo por via de e-mail Selection of Standardization Parameters and Development of Quality Control Methods for Isoleucyl-Tryptophan Dipeptide Coordination Complex with Iron(II) (Timofer)
- Autores: Bunyatyan N.1,2, Kholnazarov B.2, Olefir Y.2, Bobizoda G.2
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Afiliações:
- I. M. Sechenov First Moscow State Medical University
- State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- Edição: Volume 50, Nº 9 (2016)
- Páginas: 620-624
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244449
- DOI: https://doi.org/10.1007/s11094-016-1502-2
- ID: 244449
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Resumo
The coordination complex of the dipeptide isoleucyl-tryptophan with Fe(II) possesses immunostimulating activity and is effective for treating iron- and immunodeficiency and pulmonary, rheumatological, and urological diseases. Results are presented from the development of quantitative assays for isoleucyl-tryptophan– Fe(II) using the Fe(II) ion and the tryptophan indole moiety. The standardization parameters of a reference sample, drug substance, and its dosage form are determined.
Sobre autores
N. Bunyatyan
I. M. Sechenov First Moscow State Medical University; State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Rússia, Moscow, 119991; Moscow, 127051
B. Kholnazarov
State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Rússia, Moscow, 127051
Yu. Olefir
State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Rússia, Moscow, 127051
G. Bobizoda
State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Rússia, Moscow, 127051
