New Synthesis and Analgesic and Diuretic Activity of Halo-Substituted 4-Hydroxy-1-Methyl-2,2-Dioxo- 1H-2λ6,1-Benzothiazine-3-Carboxanilides

Abstract

A simple new method for synthesizing N-aryl-4-hydroxy-1-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides in high yields is proposed. A series of halo-substituted derivatives were synthesized. Their PMR and ¹³C NMR spectra and mass spectrometric characteristics were studied. Preliminary pharmacological screening showed that the investigated class of compounds was promising for designing potential analgesics and diuretics, thereby confirming the highly effective “flip-flop drug” methodology.