New Synthesis and Analgesic and Diuretic Activity of Halo-Substituted 4-Hydroxy-1-Methyl-2,2-Dioxo- 1H-2λ6,1-Benzothiazine-3-Carboxanilides
- Авторы: Ukrainets I.1, Petrushova L.1, Dzyubenko S.2, Grinevich L.1
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Учреждения:
- National University of Pharmacy
- N. I. Pirogov Vinnitsa National Medical University
- Выпуск: Том 50, № 9 (2016)
- Страницы: 589-594
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244443
- DOI: https://doi.org/10.1007/s11094-016-1496-9
- ID: 244443
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Аннотация
A simple new method for synthesizing N-aryl-4-hydroxy-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides in high yields is proposed. A series of halo-substituted derivatives were synthesized. Their PMR and 13C NMR spectra and mass spectrometric characteristics were studied. Preliminary pharmacological screening showed that the investigated class of compounds was promising for designing potential analgesics and diuretics, thereby confirming the highly effective “flip-flop drug” methodology.
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Об авторах
I. Ukrainets
National University of Pharmacy
Email: chem@folium.ru
Украина, Kharkiv, 61002
L. Petrushova
National University of Pharmacy
Email: chem@folium.ru
Украина, Kharkiv, 61002
S. Dzyubenko
N. I. Pirogov Vinnitsa National Medical University
Email: chem@folium.ru
Украина, Vinnitsa, 21018
L. Grinevich
National University of Pharmacy
Email: chem@folium.ru
Украина, Kharkiv, 61002