Antitumor Activity of a Polymer Composite of Etoposide and Biodegradable Poly(Lactide-Co-Glycolide)

Yu. P. Semochkina; V. G. Perevozchikova; E. Yu. Moskaleva; M. G. Ratushnyak; E. A. Vorontsov; S. L. Kuznetsov; I. A. Tubasheva; A. I. Murav’eva; S. E. Severin; G. A. Posypanova; L. B. Gorshkova; A. V. Rodina

doi:10.1007/s11094-016-1486-y

Antitumor Activity of a Polymer Composite of Etoposide and Biodegradable Poly(Lactide-Co-Glycolide)

Authors: Semochkina Y.P.¹, Perevozchikova V.G.¹, Moskaleva E.Y.¹, Ratushnyak M.G.¹, Vorontsov E.A.¹, Kuznetsov S.L.¹, Tubasheva I.A.¹, Murav’eva A.I.¹, Severin S.E.¹, Posypanova G.A.¹, Gorshkova L.B.¹, Rodina A.V.¹
Affiliations:
1. National Research Centre Kurchatov Institute
Issue: Vol 50, No 8 (2016)
Pages: 543-547
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244433
DOI: https://doi.org/10.1007/s11094-016-1486-y
ID: 244433

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Abstract

A method for preparing an antitumor polymer form of etoposide (PFE) as submicron particles based on poly(lactide-co-glycolide) with a 50:50 ratio of monomers (PLGA 50/50) was described. It was shown that the PFE possessed high cytotoxicity against various types of human tumor cells. The activity of the PFE against multiple drug resistant K562^ADR cell line was greater than that of free etoposide. A grafted solid P388 murine lymphatic leukemia model showed that the PFE exhibited high in vivo antitumor activity that was prolonged compared with that of free etoposide.

Keywords

etoposide, poly(lactide-co-glycolide), antitumor activity

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Antitumor Activity of a Polymer Composite of Etoposide and Biodegradable Poly(Lactide-Co-Glycolide)

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Abstract

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About the authors

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