Antitumor Activity of a Polymer Composite of Etoposide and Biodegradable Poly(Lactide-Co-Glycolide)
- 作者: Semochkina Y.1, Perevozchikova V.1, Moskaleva E.1, Ratushnyak M.1, Vorontsov E.1, Kuznetsov S.1, Tubasheva I.1, Murav’eva A.1, Severin S.1, Posypanova G.1, Gorshkova L.1, Rodina A.1
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隶属关系:
- National Research Centre Kurchatov Institute
- 期: 卷 50, 编号 8 (2016)
- 页面: 543-547
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244433
- DOI: https://doi.org/10.1007/s11094-016-1486-y
- ID: 244433
如何引用文章
详细
A method for preparing an antitumor polymer form of etoposide (PFE) as submicron particles based on poly(lactide-co-glycolide) with a 50:50 ratio of monomers (PLGA 50/50) was described. It was shown that the PFE possessed high cytotoxicity against various types of human tumor cells. The activity of the PFE against multiple drug resistant K562ADR cell line was greater than that of free etoposide. A grafted solid P388 murine lymphatic leukemia model showed that the PFE exhibited high in vivo antitumor activity that was prolonged compared with that of free etoposide.
作者简介
Yu. Semochkina
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
V. Perevozchikova
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
E. Moskaleva
National Research Centre Kurchatov Institute
编辑信件的主要联系方式.
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
M. Ratushnyak
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
E. Vorontsov
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
S. Kuznetsov
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
I. Tubasheva
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
A. Murav’eva
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
S. Severin
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
G. Posypanova
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
L. Gorshkova
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182
A. Rodina
National Research Centre Kurchatov Institute
Email: moskalevaey@mail.ru
俄罗斯联邦, 1 Akad. Kurchatov Sq., Moscow, 123182