Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by  1 H NMR Spectroscopy

N. E. Kuz’mina; S. V. Moiseev; V. I. Krylov; V. A. Yashkir; V. A. Merkulov

doi:10.1007/s11094-016-1435-9

Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by ¹H NMR Spectroscopy

Authors: Kuz’mina N.E.¹, Moiseev S.V.¹, Krylov V.I.¹, Yashkir V.A.¹, Merkulov V.A.¹
Affiliations:
1. Scientific Center for Expert Evaluation of Medical Products, Russian Ministry of Health
Issue: Vol 50, No 4 (2016)
Pages: 265-269
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244358
DOI: https://doi.org/10.1007/s11094-016-1435-9
ID: 244358

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Statistics

Abstract

Amethod for determining molar substitution of hydroxyethylstarches by ¹H NMR spectroscopy was validated in terms of specificity, linearity, correctness, precision, and range of application. The method can be used to evaluate the parameter “molar substitution” in the framework of pharmacological expert assessment of hydroxyethylstarches as components of medicines.