Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by  1 H NMR Spectroscopy

N. E. Kuz’mina; S. V. Moiseev; V. I. Krylov; V. A. Yashkir; V. A. Merkulov

doi:10.1007/s11094-016-1435-9

Validation of a Method for Measuring the Molar Substitution of Hydroxyethylstarches by ¹H NMR Spectroscopy

Авторы: Kuz’mina N.¹, Moiseev S.¹, Krylov V.¹, Yashkir V.¹, Merkulov V.¹
Учреждения:
1. Scientific Center for Expert Evaluation of Medical Products, Russian Ministry of Health
Выпуск: Том 50, № 4 (2016)
Страницы: 265-269
Раздел: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244358
DOI: https://doi.org/10.1007/s11094-016-1435-9
ID: 244358

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Аннотация

Amethod for determining molar substitution of hydroxyethylstarches by ¹H NMR spectroscopy was validated in terms of specificity, linearity, correctness, precision, and range of application. The method can be used to evaluate the parameter “molar substitution” in the framework of pharmacological expert assessment of hydroxyethylstarches as components of medicines.