Synthesis and Analgesic Activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides
- Authors: Gein V.L.1, Zamaraeva T.M.1, Buzmakova N.A.1, Syropyatov B.Y.1, Alikina N.V.1
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Affiliations:
- Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Issue: Vol 50, No 4 (2016)
- Pages: 226-228
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244348
- DOI: https://doi.org/10.1007/s11094-016-1427-9
- ID: 244348
Cite item
Abstract
A three-component reaction of acetoacetanilides with a mixture of an aromatic aldehyde and thiourea was used to synthesize previously unknown N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides, which had high analgesic activity and low acute toxicity.
About the authors
V. L. Gein
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Author for correspondence.
Email: geinvl@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614990
T. M. Zamaraeva
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: geinvl@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614990
N. A. Buzmakova
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: geinvl@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614990
B. Ya. Syropyatov
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: geinvl@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614990
N. V. Alikina
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: geinvl@mail.ru
Russian Federation, 2 Polevaya Street, Perm, 614990