Synthesis and Analgesic Activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

V. L. Gein; T. M. Zamaraeva; N. A. Buzmakova; B. Ya. Syropyatov; N. V. Alikina

doi:10.1007/s11094-016-1427-9

Synthesis and Analgesic Activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

Авторы: Gein V.¹, Zamaraeva T.¹, Buzmakova N.¹, Syropyatov B.¹, Alikina N.¹
Учреждения:
1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Выпуск: Том 50, № 4 (2016)
Страницы: 226-228
Раздел: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244348
DOI: https://doi.org/10.1007/s11094-016-1427-9
ID: 244348

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Аннотация

A three-component reaction of acetoacetanilides with a mixture of an aromatic aldehyde and thiourea was used to synthesize previously unknown N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides, which had high analgesic activity and low acute toxicity.