Email this article Convenient Four-Step Synthesis of H-Pyr-His-Trp-OH, a Key Tripeptide Intermediate for the Production of Synthetic Gonadoliberin Agonists
- Authors: Balaev A.N.1, Okhmanovich K.A.1, Fedorov V.E.1
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Affiliations:
- Pharm-Sintez Co., 8 2nd Roshchinskii Proezd
- Issue: Vol 50, No 3 (2016)
- Pages: 192-194
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244342
- DOI: https://doi.org/10.1007/s11094-016-1421-2
- ID: 244342
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Abstract
An effective four-step synthesis of the tripeptide H-Pyr-His-Trp-OH that is used to produce synthetic gonadoliberin agonists was developed. The synthesis was carried out without adding and removing protecting groups and could produce the target compound with >98% purity.
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About the authors
A. N. Balaev
Pharm-Sintez Co., 8 2nd Roshchinskii Proezd
Email: chem@folium.ru
Russian Federation, Moscow, 115419
K. A. Okhmanovich
Pharm-Sintez Co., 8 2nd Roshchinskii Proezd
Email: chem@folium.ru
Russian Federation, Moscow, 115419
V. E. Fedorov
Pharm-Sintez Co., 8 2nd Roshchinskii Proezd
Email: chem@folium.ru
Russian Federation, Moscow, 115419
