Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs
- Authors: Bozhok T.S.1, Kalinichenko E.N.1, Kuz’mitskii B.B.1, Golubeva M.B.1
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Affiliations:
- Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
- Issue: Vol 49, No 12 (2016)
- Pages: 804-809
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244296
- DOI: https://doi.org/10.1007/s11094-016-1375-4
- ID: 244296
Cite item
Abstract
New azacytidine nucleoside analogs with modified carbohydrate moieties were synthesized. Screening identified a highly active 2′-fluoro-containing azacytidine analog that could potentially be of interest as an agent for treating acute myelogenous leukemia and myelodysplastic syndrome.
About the authors
T. S. Bozhok
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Email: kalinichenko@iboch.bas-net.by
Belarus, 5/2 Akad. V. F. Kuprevicha St., Minsk, 220141
E. N. Kalinichenko
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Author for correspondence.
Email: kalinichenko@iboch.bas-net.by
Belarus, 5/2 Akad. V. F. Kuprevicha St., Minsk, 220141
B. B. Kuz’mitskii
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Email: kalinichenko@iboch.bas-net.by
Belarus, 5/2 Akad. V. F. Kuprevicha St., Minsk, 220141
M. B. Golubeva
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Email: kalinichenko@iboch.bas-net.by
Belarus, 5/2 Akad. V. F. Kuprevicha St., Minsk, 220141