Email this article Modern Technologies for Synthesizing Drug Substances: Toward Highly Efficient Drug Production
- Authors: Narkevich I.A.1, Tarasov I.N.2, Golant Z.M.1, Alekhin A.V.3
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Affiliations:
- St. Petersburg State Chemico-Pharmaceutical Academy, Russian Ministry of Health
- MicroSpin MRT GmbH
- RF Ministry of Industry and Trade
- Issue: Vol 49, No 11 (2016)
- Pages: 760-764
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244287
- DOI: https://doi.org/10.1007/s11094-016-1366-5
- ID: 244287
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Abstract
Implementation of new technologies for synthesizing drug substances, e.g., continuous-flow microreactor synthesis of active drug substances (ADS) and asymmetric synthesis of intermediates and ADS using enzymes created by gene engineering methods, is highly significant for localizing ADS production in Russia. The possibility of using the existing Russian scientific infrastructure for rapid implementation of domestic production of a new ADS portfolio with the least operating losses, maximum economic efficiency, and high competitiveness was demonstrated.
About the authors
I. A. Narkevich
St. Petersburg State Chemico-Pharmaceutical Academy, Russian Ministry of Health
Author for correspondence.
Email: igor.narkevich@pharminnotech.com
Russian Federation, 14 Prof. Popova St., St. Petersburg, 197022
I. N. Tarasov
MicroSpin MRT GmbH
Email: igor.narkevich@pharminnotech.com
Germany, 21 Zaarland St., Wolfach, 77709
Z. M. Golant
St. Petersburg State Chemico-Pharmaceutical Academy, Russian Ministry of Health
Email: igor.narkevich@pharminnotech.com
Russian Federation, 14 Prof. Popova St., St. Petersburg, 197022
A. V. Alekhin
RF Ministry of Industry and Trade
Email: igor.narkevich@pharminnotech.com
Russian Federation, 7 Kitaigorodskii Proezd, Moscow, 109074
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