Antidiabetic and Antilipidemic Effects of Some Polar and Nonpolar Extracts of Securigera Securidaca Flowers

Abstract

Medicinal plants are widely used for pharmacological agents. These herbs are very rich sources of bioactive compounds. Securigera securidaca is reputed in folk medicine as antidiabetic and antilipidemic drug. In this research, the effect of solvent’s polarity in bioactive extract of this plant was evaluated by GC/MS analysis. Then, hypoglycemic and hypolipidemic activities of different extracts were studied in diabetic rats and compared to glibenclamide.The results showed that carbon tetrachloride extract of this plant has the best and significant activity for reducing of glucose and lipid levels compared to other extracts because of higher content of sterols and fatty acids.