Synthesis of Diethyl 6-Amino-1-aryl-2-oxo-1,2-dihydropyridine-3,5-carboxylate
- Autores: Khachatryan A.1,2, Avagyan K.1, Badasyan A.1
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Afiliações:
- Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Crisis Management State Academy of the Ministry of Internal Affairs
- Edição: Volume 94, Nº 4 (2024)
- Páginas: 462-468
- Seção: Articles
- URL: https://journals.rcsi.science/0044-460X/article/view/262777
- DOI: https://doi.org/10.31857/S0044460X24040011
- EDN: https://elibrary.ru/ECIZJX
- ID: 262777
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Resumo
It was found that the reaction of malonic acid N-arylamidoesters with ethyl 2-cyano-3-ethoxyacrylate in ethanol in the presence of equimolar amounts of triethylamine both at room temperature and under reflux leads to the formation of previously unknown diethyl 6-amino-1-aryl-2-oxo-1,2-dihydropyridine-3,5-carboxylates with yields of 40–70%. Structure of the obtained compounds was confirmed by NMR and IR spectroscopy data. Antibacterial activity of some of the obtained compounds was studied.
Texto integral
Sobre autores
A. Khachatryan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia; Crisis Management State Academy of the Ministry of Internal Affairs
Autor responsável pela correspondência
Email: avagyan9248@gmail.com
ORCID ID: 0000-0003-1210-9903
Armênia, Yerevan, 0014; Yerevan, 0040
K. Avagyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: avagyan9248@gmail.com
ORCID ID: 0000-0002-5370-041X
Armênia, Yerevan, 0014
A. Badasyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: avagyan9248@gmail.com
ORCID ID: 0009-0003-6123-9867
Armênia, Yerevan, 0014
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