Enviar artigo por via de e-mail Search for Monoamine Oxidase Inhibitors among Pyrazoline and Pyrimidine Derivatives and Studying Luminescent Properties of the Obtained Compounds
- Autores: Isakhanyan A.1, Hakobyan N.1, Hovasyan Z.1, Grigoryan G.2, Mkhitaryan R.2, Yesayan D.2, Grigoryan A.1, Gasparyan H.1, Panosyan Н.1, Harutyunyan A.1
-
Afiliações:
- Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Yerevan State University
- Edição: Volume 94, Nº 1 (2024)
- Páginas: 80-91
- Seção: Articles
- URL: https://journals.rcsi.science/0044-460X/article/view/258228
- DOI: https://doi.org/10.31857/S0044460X24010065
- EDN: https://elibrary.ru/HLHZQA
- ID: 258228
Citar
Acesso aberto
Acesso está concedido
Resumo
Cyclization of the (E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones with phenylhydrazine in an acidic medium leads to the 5-aryl-3-(4-alkoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazoles. Bubbling air through a solution of 5-(4-methoxyphenyl)-1-phenyl-3-(4-ethoxyphenyl)-4,5-dihydro-1H-pyrazole in ethylcellosolve resulted in an oxidation-dehydrogenation product, which characterized as the picrate of the corresponding pyrazole. The reaction of benzamidine and 4-methylbenzamidine hydrochlorides with substituted chalcones in а KOH–ethanol system leads to 2,4-diaryl-6-(4-alkoxyphenyl)pyrimidines. The luminescent and antimonoamine oxidase properties of the resulting systems were studied.
Texto integral
Sobre autores
A. Isakhanyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Autor responsável pela correspondência
Email: anush.isakhanyan.51@mail.ru
ORCID ID: 0000-0002-1713-4908
Armênia, Yerevan
N. Hakobyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID ID: 0000-0002-3095-5938
Armênia, Yerevan
Z. Hovasyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID ID: 0000-0001-6698-7184
Armênia, Yerevan
G. Grigoryan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID ID: 0000-0002-0675-735X
Armênia, Yerevan
R. Mkhitaryan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID ID: 0009-0009-6277-2747
Armênia, Yerevan
D. Yesayan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID ID: 0009-0008-7243-6248
Rússia, Yerevan
A. Grigoryan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID ID: 0000-0002-3834-3338
Rússia, Yerevan
H. Gasparyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID ID: 0000-0002-8555-3733
Rússia, Yerevan
Н. Panosyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID ID: 0000-0001-8311-6276
Rússia, Yerevan
A. Harutyunyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID ID: 0000-0003-0641-5453
Rússia, Yerevan
Bibliografia
- Чиряпкин А.С. // Juvenis Scientia. 2022. Т. 8. № 5. С. 16. doi: 10.32415/jscientia_2022_8, 5,_16-30
- Varghese B., Al-Busafi S.N., Suliman F.O., Al-Kindy S.M.Z. // RSC Adv. 2017. Vol. 7. N 74. P. 46999. doi: 10.1039/c7ra08939b
- Kumar S., Bawa S., Drabu S., Kumar R., Gupta H. // Recent Pat. Antiinfect. Drug Discov. 2009. Vol. 4. N 3. P. 154. doi: 10.2174/157489109789318569
- Nehra B., Rulhania S., Jaswal S., Kumar B., Singh G., Monga V. // Eur. J. Med. Chem. 2020. Vol. 205. P. 112666. doi: 10.1016/j.ejmech.2020.112666
- Matiadis D., Sagnou M. // Int. J. Mol. Sci. 2020. Vol. 21. N 15. P. 5507. doi: 10.3390/ijms21155507
- Deng H., Yu Z.Y., Shi G.Y., Chen M.J., Tao K., Hou T.P. // Chem. Biol. Drug Des. 2012. Vol. 79. N 3. P. 279. doi: 10.1111/j.1747-0285.2011.01308.x
- Машковский М.Д. Лекарственные средства. М.: Новая волна, 2010. С. 851.
- Guglielmi P., Carradori S., Poli G., Secci D., Cirilli R., Rotondi G., Chimenti P., Petzer A., Petzer J.P. // Molecules. 2019. Vol. 24. N 3. Р. 484. doi: 10.3390/molecules24030484
- Исаханян А.У., Акопян Н.З., Овасян З.А., Григорян Г.С., Мхитарян Р.П., Аракелян А.Г., Сафарян А.С., Мурадян Р.Е., Паносян Г.А., Арутюнян А.А. // ЖОХ. 2023. Т. 93. № 9. С. 1335; Isakhanyan A.U., Hakobyan N.Z., Hovasyan Z.A., Grigoryan G.S., Mkhitaryan R.P., Aracelyan H.G., Safaryan A.S., Muradyan R.E., Panosyan Н.A., Harutyunyan A.A. // Russ. J. Gen. Chem. 2023. Vol. 93. N 9. P. 2210. doi: 10.1134/S1070363223090037
- Lakowicz J.R. Principles of Fluorescence Spectroscopy. New York: Springer, 2006. P. 954. doi: 10.1007/978-0-387-46312-4
- Brouwer A.M. // Pure Appl. Chem. 2011. Vol. 83. N 12. P. 2213. doi: 10.1351/PAC-REP-10-09-31
- Shivananda M.K., Holla B.S. // J. Chem. Pharm. Res. 2017. Vol. 9. N 6. P. 1.
Arquivos suplementares
