Synthesis of 5-Aryl-1-[2-(1H-indol-3-yl)ethyl]- 4-(hydroxy-4-methylphenylmethylene)pyrrolidine-2,3-diones by Reaction of Tryptamine with 4-Methylbenzoyltartaric Acid Methyl Ester and Aromatic Aldehydes

M. I. Kazantseva; Казанцева М. И.; N. N. Kasimova; Касимова Наталья Нурисламовна; V. L. Gein; Гейн Владимир Леонидович

doi:10.31857/S0044460X24030041

Synthesis of 5-Aryl-1-[2-(1H-indol-3-yl)ethyl]- 4-(hydroxy-4-methylphenylmethylene)pyrrolidine-2,3-diones by Reaction of Tryptamine with 4-Methylbenzoyltartaric Acid Methyl Ester and Aromatic Aldehydes

Authors: Kazantseva M.I.¹, Kasimova N.N.², Gein V.L.²
Affiliations:
1. E. A. Wagner Perm State Medical University
2. Perm State Pharmaceutical Academy
Issue: Vol 94, No 3 (2024)
Pages: 350-357
Section: Articles
URL: https://journals.rcsi.science/0044-460X/article/view/261496
DOI: https://doi.org/10.31857/S0044460X24030041
EDN: https://elibrary.ru/FZGOXH
ID: 261496

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Abstract
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Abstract

Short heating of a mixture of tryptamine, aromatic aldehyde and 4-methylbenzoylpyruvic acid methyl ester followed by keeping for 24 h at room temperature leads to the formation of 5-aryl-1-[2-(1H-indol-3-yl)ethyl]-4-(hydroxy-p-tolylmethylene)pyrrolidine-2,3-diones. Structure of the obtained compounds was confirmed by IR and 1H NMR spectroscopy methods. Antimicrobial activity of the obtained compounds was investigated.

Keywords

pyrrolidine-2, 3-diones, N,N-dimethyltryptamine analogues, three-component reactions, biologically active substances, antimicrobial activity

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About the authors

M. I. Kazantseva

E. A. Wagner Perm State Medical University

Email: pufmail135@gmail.com
Russian Federation, Perm, 614990

N. N. Kasimova

Perm State Pharmaceutical Academy

Author for correspondence.
Email: pufmail135@gmail.com
ORCID iD: 0009-0001-6348-7333
Russian Federation, Perm, 614990

V. L. Gein

Perm State Pharmaceutical Academy

Email: pufmail135@gmail.com
ORCID iD: 0000-0002-8512-0399
Russian Federation, Perm, 614990

References

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