Development of a reproducible and scalable method for the synthesis of biologically active pyrazolo[1,5-a]pyrimidine derivatives
- 作者: Novikova D.1, Darwish F.1, Grigoreva T.1, Tribulovich V.1
-
隶属关系:
- St. Petersburg State Institute of Technology (Technical University)
- 期: 卷 93, 编号 5 (2023)
- 页面: 684-694
- 栏目: Articles
- URL: https://journals.rcsi.science/0044-460X/article/view/145045
- DOI: https://doi.org/10.31857/S0044460X23050049
- EDN: https://elibrary.ru/DBOQGZ
- ID: 145045
如何引用文章
详细
A reproducible and scalable method for the synthesis was developed, and a series of 3,6-substituted pyrazolo[1,5- a ]pyrimidines, which are the basis for the rational design of selective inhibitors of AMP-activated protein kinase, was obtained and characterized. In the course of the formation of new types of carbon skeleton, the possibility of applying Suzuki-Miyaura cross-coupling with Buchwald ligands to form C-C bond in the sterically hindered position 6 of 5,7-dimethyl-substituted pyrazolo[1,5- a ]pyrimidine was shown.
作者简介
D. Novikova
St. Petersburg State Institute of Technology (Technical University)
Email: dc.novikova@gmail.com
F. Darwish
St. Petersburg State Institute of Technology (Technical University)
T. Grigoreva
St. Petersburg State Institute of Technology (Technical University)
V. Tribulovich
St. Petersburg State Institute of Technology (Technical University)
参考
- Trefts E., Shaw R.J. // Mol. Cell. 2021. Vol. 81. N 18. P. 3677. doi: 10.1016/j.molcel.2021.08.015
- Tarasiuk O., Miceli M., Di Domizio A., Nicolini G. // Biology. 2022. Vol. 11. N 7. P. 1041. doi: 10.3390/biology11071041
- Новикова Д.С., Гарабаджиу А.В., Мелино Дж., Барлев Н.А., Трибулович В.Г. // Изв. АН. Сер. хим. 2015. № 7. С. 1497
- Novikova D.S., Garabadzhiu A.V., Melino G., Barlev N.A., Tribulovich V.G. // Russ. Chem. Bull. 2015. Vol. 64. N 7. P. 1497. doi: 10.1007/s11172-015-1036-x
- Russell F.M., Hardie D.G. // Int. J. Mol. Sci. 2021. Vol. 22. N 1. P. 186. doi: 10.3390/ijms22010186
- Novikova D.S., Grigoreva T.A., Ivanov G.S., Barlev N.A., Tribulovich V.G. // ChemMedChem. 2020. Vol. 15. N 24. P. 2521. doi: 10.1002/cmdc.202000579
- Novikova D.S., Grigoreva T.A., Zolotarev A.A., Garabadzhiu, A.V., Tribulovich, V.G. // RSC Adv. 2018. Vol. 8. N 60., P. 34543. doi: 10.1039/C8RA07576J
- Dasgupta B., Seibel W. // Methods Mol. Biol. 2018. Vol. 1732. P. 195. doi: 10.1007/978-1-4939-7598-3_12
- Dite T.A., Langendorf C.G., Hoque A., Galic S., Rebello R.J., Ovens A.J., Lindqvist L.M., Ngoei K.R.W., Ling N.X.Y., Furic L., Kemp B.E., Scott J.W., Oakhill J.S. // J. Biol. Chem. 2018. Vol. 293. N 23. P. 8874. doi: 10.1074/jbc.RA118.003547
- Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M.F., Goodyear L.J., Moller D.E. // J. Clin. Invest. 2001. Vol. 108. N 8. P. 1167. doi: 10.1172/JCI13505
- Fraley M.E., Rubino R.S., Hoffman W.F., Hambaugh S.R., Arrington K.L., Hungate R.W., Bilodeau M.T., Tebben A.J., Rutledge R.Z., Kendall R.L., McFall R.C., Huckle W.R., Coll K.E., Thomas K.A. // Bioorg. Med. Chem. Lett. 2002. Vol. 12. N 24. P. 3537. doi: 10.1016/s0960-894x(02)00827-2
- Cuny G.D., Yu P.B., Laha J.K., Xing X., Liu J.F., Lai C.S., Deng D.Y., Sachidanandan C., Bloch K.D., Peterson R.T. // Bioorg. Med. Chem. Lett. 2008. Vol. 18. N 15. P. 4388. doi: 10.1016/j.bmcl.2008.06.052
- Cherukupalli S., Karpoormath R., Chandrasekaran B., Hampannavar G.A., Thapliyal N., Palakollu V.N. // Eur. J. Med. Chem. 2017. Vol. 126. P. 298. doi: 10.1016/j.ejmech.2016.11.019
- Arias-Gómez A., Godoy A., Portilla J. // Molecules. 2021. Vol. 26. N 9. P. 2708. doi: 10.3390/molecules26092708
- Moszczyński-Pętkowski R., Majer J., Borkowska M., Bojarski Ł., Janowska S., Matłoka M., Stefaniak F., Smuga D., Bazydło K., Dubiel K., Wieczorek M. // Eur. J. Med. Chem. 2018. Vol. 155. P. 96. doi: 10.1016/j.ejmech.2018.05.043
- Prasanth C.P., Ebbin J., Abhijith A., Nair D.S., Ibnusaud I., Raskatov J., Singaram B. // J. Org. Chem. 2018. Vol. 83. N 3. P. 1431. doi: 10.1021/acs.joc.7b02993
- Rüger N., Roatsch M., Emmrich T., Franz H., Schüle R., Jung M., Link A. // ChemMedChem. 2015. Vol. 10. N 11. P. 1875. doi: 10.1002/cmdc.201500335
- Kaushik M.P., Vaidyanathaswamy R. // Phosphorus, Sulfur, Silicon, Relat. Elem. 1995. Vol. 102. N 1-4. P. 45. doi: 10.1080/10426509508042541
- Borne R.F., Aboul-Enein H.Y. // J. Heterocycl. Chem. 1980. Vol. 17. N 7. P. 1609. doi: 10.1002/jhet.5570170753
- Demchuk O.P., Hryshchuk O.V., Vashchenko B.V., Radchenko D.S., Kovtunenko V.O., Komarov I.V., Grygorenko O.O. // Eur. J. Org. Chem. 2019. Vol. 2019. N 34. P. 5937. doi: 10.1002/ejoc.201901001
- Trofimenko S. // J. Org. Chem. 1963. Vol. 28. N 11. P. 3243. doi: 10.1021/jo01046a526
- Tomsho J.W., McGuireb J.J., Coward J.K. // Org. Biomol. Chem. 2005. Vol. 3. N 18. P. 3388. doi: 10.1039/B505907K
- Chen H.J., Chew C.Y., Chang E.H., Tu Y.W., Wei L.Y., Wu B.H., Chen C.H., Yang Y.T., Huang S.C., Chen J.K., Chen I.C., Tan K.T. // J. Am. Chem. Soc. 2018. Vol. 140. N 15. P. 5224. doi: 10.1021/jacs.8b01159
- Tribulovich V.G., Garabadzhiu A.V., Kalvin'sh I. // Pharm. Chem. J. 2011. Vol. 45. N 4. P. 241. doi: 10.1007/s11094-011-0605-z
- Barder T.E., Walker S.D., Martinelli J.R., Buchwald S.L. // J. Am. Chem. Soc. 2005. Vol. 127. N 13. P. 4685. doi: 10.1021/ja042491j