Derivatives of the closo-Decaborate Anion with Pendant Functional Groups as Inhibitors of Viral Replication
- Авторлар: Grebennikova T.1, Avdeeva V.2, Malinina E.2, Zhizhin K.2,3, Kuznetsov N.2, Matveev E.2,3, Garaev T.1, Novikov S.3, Nichugovskii A.3, Sokolov I.3, Larichev V.1, Lebedeva V.1
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Мекемелер:
- National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
- Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
- Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
- Шығарылым: Том 68, № 6 (2023)
- Беттер: 752-760
- Бөлім: СИНТЕЗ И СВОЙСТВА НЕОРГАНИЧЕСКИХ СОЕДИНЕНИЙ
- URL: https://journals.rcsi.science/0044-457X/article/view/136468
- DOI: https://doi.org/10.31857/S0044457X22602413
- EDN: https://elibrary.ru/UGAEWC
- ID: 136468
Дәйексөз келтіру
Аннотация
The reaction between the 1,4-dioxane derivative of the closo-decaborate anion [2-B10H9O(CH2)4O]– with cyanide, hydrophthalate, and hydroiminoacetate ions has been studied. Alkali metal salts (K, Na, and Cs) of the closo-decaborate anion derivatives with pendant groups –NHCH2CH2NH2-, –OOC(o-C6H4)COOH-, –OOCCH2NHCH2COOH-, –OCH2CH2OH-, –CN-, –SCN-, and –SH- have been isolated. All compounds have been shown to have extremely low cytotoxicity (CT50 ~ 1000 μg/mL). It has been found that compounds Na2[B10H9O(CH2)2O(CH2)2SCN] and Na2[B10H9O(CH2)2O(CH2)2CN] exhibit activity and selectivity in vitro against the modern strain of SARS-CoV-2 coronavirus (IC50 312 and 625 μg/mL, respectively). In relation to influenza A virus and rabies virus, the compounds show weak antiviral activity at high concentrations (1250 μg/mL), i.e. show no selective effect on the reproduction of these viruses.
Авторлар туралы
T. Grebennikova
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: cat1983@yandex.com
123098, Moscow, Russia
V. Avdeeva
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: cat1983@yandex.com
119991, Moscow, Russia
E. Malinina
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: cat1983@yandex.com
119991, Moscow, Russia
K. Zhizhin
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: cat1983@yandex.ru
119991, Moscow, Russia; 119571, Moscow, Russia
N. Kuznetsov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: avdeeva.varvara@mail.ru
119991, Moscow, Russia
E. Matveev
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: cat1983@yandex.ru
119991, Moscow, Russia; 119571, Moscow, Russia
T. Garaev
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: cat1983@yandex.com
123098, Moscow, Russia
S. Novikov
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: cat1983@yandex.com
119571, Moscow, Russia
A. Nichugovskii
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: cat1983@yandex.com
119571, Moscow, Russia
I. Sokolov
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: cat1983@yandex.com
119571, Moscow, Russia
V. Larichev
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: cat1983@yandex.com
123098, Moscow, Russia
V. Lebedeva
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: cat1983@yandex.com
123098, Moscow, Russia
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