Vimentin in Kolmer cells of spontaneously hypertensive rats
- 作者: Korzhevskii D.1, Razenkova V.1, Kirik O.1
-
隶属关系:
- Institute of Experimental Medicine
- 期: 卷 66, 编号 1 (2024)
- 页面: 77-84
- 栏目: Articles
- URL: https://journals.rcsi.science/0041-3771/article/view/256175
- DOI: https://doi.org/10.31857/S0041377124010075
- EDN: https://elibrary.ru/IBBWCG
- ID: 256175
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详细
Epiplexus (Kolmer) cells are macrophage-like cells of the choroid plexus that help maintain the blood-cerebrospinal fluid barrier. Here we studied the structural organization of Kolmer cells in Wistar, Wistar-Kyoto and spontaneously hypertensive (SHR) rats. A comparative study using Iba-1, CD68 and vimentin immunohistochemistry showed that the functional activity of epiplexus cells differs in three examined groups of animals. Wistar-Kyoto and SHR rats showed noticeable signs of Kolmer cells activation, which consisted in the disappearance of cell processes resulting in the formation of round-shaped cells. Another significant observation was the presence of vimentin in activated epiplexus cells. The result obtained indicates that vimentin expression by phagocytic cells could be linked with their activation.
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作者简介
D. Korzhevskii
Institute of Experimental Medicine
Email: valeriya.raz@yandex.ru
俄罗斯联邦, St. Petersburg
V. Razenkova
Institute of Experimental Medicine
编辑信件的主要联系方式.
Email: valeriya.raz@yandex.ru
俄罗斯联邦, St. Petersburg
O. Kirik
Institute of Experimental Medicine
Email: valeriya.raz@yandex.ru
俄罗斯联邦, St. Petersburg
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