The experience of using the Russian biosimilar of the original drug eculizumab for the treatment of patients with atypical hemolytic-uremic syndrome
- 作者: Lavrishcheva Y.1, Yakovenko A.2, Kudlai D.3
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隶属关系:
- Almazov National Medical Research Centre
- Pavlov First Saint Petersburg State Medical University
- JSC GENERIUM
- 期: 卷 92, 编号 6 (2020)
- 页面: 76-80
- 栏目: Consensuns
- URL: https://journals.rcsi.science/0040-3660/article/view/35000
- DOI: https://doi.org/10.26442/00403660.2020.06.000649
- ID: 35000
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详细
Atypical hemolytic-uremic syndrome (aHUS) is a chronic systemic disease of a genetic nature, which is based on uncontrolled activation of the alternative complement pathway, leading to generalized thrombosis in the vessels of the microvasculature (complement-mediated thrombotic microangiopathy). To date, therapy with eculizumab is the most effective and pathogenetically substantiated method of treating patients with ASH. Using the example of three clinical cases of patients with a verified diagnosis of aHUS, the high efficiency and safety of the world’s first bioanalogue of eculizumab in the treatment of adult patients with aHUS (complement-mediated thrombotic microangiopathy) was demonstrated.
作者简介
Yulia Lavrishcheva
Almazov National Medical Research Centre
编辑信件的主要联系方式.
Email: lavrischeva@gmail.com
ORCID iD: 0000-0002-3073-2785
врач-нефролог
俄罗斯联邦, MoscowAlexander Yakovenko
Pavlov First Saint Petersburg State Medical University
Email: lavrischeva@gmail.com
ORCID iD: 0000-0003-1045-9336
канд. мед. наук, доц. каф. нефрологии и диализа
俄罗斯联邦, MoscowDmitrii Kudlai
JSC GENERIUM
Email: lavrischeva@gmail.com
д-р мед. наук, ген. дир.
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