Endothelial dysfunction in patients with chronic obstructive pulmonary disease in combination with coronary heart disease
- 作者: Karoli N1, Rebrov A1
-
隶属关系:
- V.I. Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation
- 期: 卷 91, 编号 3 (2019)
- 页面: 22-26
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/33007
- DOI: https://doi.org/10.26442/00403660.2019.03.000061
- ID: 33007
如何引用文章
全文:
详细
Chronic obstructive pulmonary disease is associated with increased cardiovascular mortality. Endothelial dysfunction may underpin this association. Vascular endothelial dysfunction is known to be an important prognostic marker for cardiovascular events. The aim of this study was to evaluate the state of the vascular wall in patients with chronic obstructive pulmonary disease (COPD) combined with chronic coronary artery disease (CAD). Materials and methods. The study included 108 patients: 37 patients with COPD and CAD and 71 patients with COPD without CAD. Endothelial function was studied in tests with reactive hyperemia and nitroglycerin. The number of blood plasma desquamated endotheliocytes were determined by the Hladovec method. In patients with COPD identified are signs of vascular wall remodeling: thickening wall of the brachial artery, reduction of the flow-mediated vasodilation. Patients with COPD in combination with CHD demonstrated higher impairments of the vasoregulatory dysfunction of endothelial of the vascular wall. Conclusion. In patients with COPD combined with chronic coronary heart disease more pronounced endothelial dysfunction with disturbance of endothelium-dependent vasomotor reactions.
作者简介
N Karoli
V.I. Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation
Email: nina.karoli.73@gmail.com
д.м.н., проф. каф. госпитальной терапии лечебного фак-та; тел.: +7(917)213-69-86; e-mail: nina.karoli.73@ gmail.com; ORCID: 0000-0002-7464-826X Saratov, Russia
A Rebrov
V.I. Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federationд.м.н., зав. каф. госпитальной терапии лечебного фак-та Saratov, Russia
参考
- Global Strategy for diagnosis, management and prevention of COPD. Scientific information and recommendations for COPD programs. Updated 2013. http://www.goldcopd.org/uploads/users/files/GOLD_Report_2013Feb13.pdf
- Engstrom G, Lind P, Hedblad B, et al. Lung function and cardiovascular risk. Circulation. 2002;106(20):2555-60.
- Sin D.D, Wu L, Man S.F. The relationship between reduced lung function and cardiovascular mortality: a population - based study and a systematic review of the literature. Chest. 2005;127(6):1952-9. https:// doi: 10.1378/chest.127.6.1952
- Sin D.D, Anthonisen N.R, Soriano J.B, Agusti A.G. Mortality in COPD: role of comorbidities. Eur Respir J. 2006;28(6):1245-57. 10.1183/09031936.00133805' target='_blank'>https://doi: 10.1183/09031936.00133805
- Macnee W, Maclay J, Mc Allister D. Cardiovascular injury and repair in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008;5(8):824-33. 10.1513/pats.200807-071TH' target='_blank'>https://doi: 10.1513/pats.200807-071TH
- Decramer M, Janssens W. Chronic obstructive pulmonary disease and comorbidities. Lancet Respir Med. 2013;1(1):73-83. 10.1016/S2213-2600(12)70060-7' target='_blank'>https://doi: 10.1016/S2213-2600(12)70060-7
- Pływaczewski R, Maciejewski J, Bednarek M, Zieliński J, et al. Causes of deaths in COPD patients in primary care setting - a 6-year follow - up. Pneumonol Alergol Pol. 2015;83(3):193-202. https://doi: 10.5603/ PiAP.2015.0031
- Curkendall S.M, De Luise C, Jones J.K, et al. Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada: cardiovascular disease in COPD patients. Ann Epidemiol. 2006;16(1):63-70. 10.1016/j.annepidem.2005.04.008' target='_blank'>https://doi: 10.1016/j.annepidem.2005.04.008
- Sabit R, Thomas P, Shale D.J, et al. The effects of hypoxia on markers of coagulation and systemic inflammation in patients with COPD. Chest. 2010;138(1):47-51. https://doi: 10.1378/chest.09-2764
- Mac Nee W. Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2(1):50-60. https://doi: 10.1513/pats.200411-056SF
- Watz H, Waschki B, Boehme C, et al. Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross - sectional study. Am J Respir Crit Care Med. 2008;177(7):743-51. https://doi: 10.1164/rccm.200707-1011OC
- Waschki B, Kirsten A, Holz O, et al. Physical activity is the strongest predictor of all - cause mortality in patients with COPD: a prospective cohort study. Chest. 2011;140(2):331-42. https://doi: 10.1378/chest. 10-2521
- Кароли Н.А., Ребров А.П. Вазорегулирующая активность эндотелия и легочная гипертензия. Терапевтический архив. 2004;76(12):39-44.
- Rubinshtein R, Kuvin J.T, Soffler M, et al. Assessment of endothelial function by non - invasive peripheral arterial tonometry predicts late cardiovascular adverse events. Eur Heart J. 2010;31(9):1142-8. 10.1093/eurheartj/ehq010' target='_blank'>https://doi: 10.1093/eurheartj/ehq010
- Lind L, Berglund L, Larsson A, et al. Endothelial function in resistance and conduit arteries and 5-year risk of cardiovascular disease. Circulation. 2011;123:1545-51. 10.1161/CIRCULATIONAHA' target='_blank'>https://doi: 10.1161/CIRCULATIONAHA. 110.984047
- Gokce N, Keaney J.F.Jr, Hunter L.M, et al. Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation. 2002;105(13):1567-72.
- Celermajer D.S, Sorensen K.E, Gooch V.M, et al. Non - invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340(8828):1111-5.
- Кароли Н.А., Ребров А.П. Коморбидность у больных ХОБЛ: место кардиоваскулярной патологии. Рациональная фармакотерапия в кардиологии. 2009;4:9-16.
- Weidinger F, Frick M, Alber H.F, et al. Association of wall thickness of the brachial artery measured with high - resolution ultrasound with risk factors and coronary artery disease. Am J Cardiol. 2002;89(9):1025-9.
- Urban M.H, Eickhoff P, Funk G.K, et al. Increased brachial intima - media thickness is associated with circulating levels of asymmetric dimethylarginine in patients with COPD. Int J of COPD. 2017;12:169-76. https://doi: 10.2147/COPD.S118596
- Chandra D, Gupta A, Strollo P.J. Jr, Fuhrman C.R, Leader J.K, Bon J, Slivka W.A, Shoushtari A.H, Avolio J, Kip K.E, Reis S, Sciurba F.C. Airflow Limitation and Endothelial Dysfunction. Unrelated and Independent Predictors of Atherosclerosis. Am J Respir Crit Care Med. 2016;194(1):38-47. 10.1164/rccm.201510-2093OC' target='_blank'>https://doi: 10.1164/rccm.201510-2093OC
- Anderson T.J, Uehata A, Gerhard M.D, Meredith I.T, Knab S, Delagrange D, Lieberman E.H, Ganz P, Creager M.A, Yeung A.C, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995;26(5):1235-41.
- Neunteufl T, Katzenschlager R, Hassan A, Klaar U, Schwarzacher S, Glogar D, Bauer P, Weidinger F. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis. 1997;129(1):111-8.
- Thijssen D.H, Black M.A, Pyke K.E, Padilla J, Atkinson G, Harris R.A, Parker B, Widlansky M.E, Tschakovsky M.E, Green D.J. Assessment of flowmediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol. 2011;300(1):H2-12. https://doi: 10.1152/ajpheart.00471.2010
- Clarenbach C.F, Senn O, Sievi N.A, Camen G, et al. Determinants of endothelial function in patients with COPD. Eur Respir J. 2013;42(5):1194-204. https://doi: 10.1183/09031936.00144612
- Clarenbach C.F, Sievi N.A, Brock M, et al. Lung Volume Reduction Surgery and Improvement of Endothelial Function and Blood Pressure in Patients with Chronic Obstructive Pulmonary Disease. A Randomized Controlled Trial. Am J Respir Crit Care Med. 2015;192(3):307-14. 10.1164/rccm.201503-0453OC' target='_blank'>https://doi: 10.1164/rccm.201503-0453OC
- Eickhoff P, Valipour A, Kiss D, Schreder M, Cekici L, Geyer K, Kohansal R, Burghuber O.C. Determinants of systemic vascular function in patients with stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;178:1211-8. https://doi: 10.1164/rccm.200709-1412OC
- Попова М.А., Долгополова Д.А., Терентьева Н.Н. Особенности эндотелиальной дисфункции у больных ишемической болезнью сердца, протекающей в коморбидности с хронической обструктивной болезнью легких. Ульяновский медико - биологический журнал. 2016;1:32-9.