Prognostic factors in patients with hematological malignancies and concomitant chronic hepatitis C
- Authors: Nozhkin M.S.1, Lioznov D.A.1,2, Antonova T.V.1, Gorchakova O.V.1, Goldstein E.M.3, Popova M.O.1, Shneyder T.V.4
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Affiliations:
- Pavlov First Saint Petersburg State Medical University
- Smorodintsev Research Institute of Influenza
- Harvard T.H. Chan School of Public Healt
- Leningrad Regional Clinical Hospital
- Issue: Vol 95, No 11 (2023)
- Pages: 919-923
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/231996
- DOI: https://doi.org/10.26442/00403660.2023.11.202473
- ID: 231996
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Abstract
The study evaluated the impact of HCV infection on the prognosis in patients with hematological malignancies. A total of 96 patients with anti-HCV antibodies were enrolled, with the age of 37.8 (3.0–81.0) years old, 39.6% had non-Hodgkin’s lymphoma. Chronic hepatitis C (CHC) was diagnosed in 46.9% patients prior to malignancy development, in 38.5% patients simultaneously with malignancy, and in 14.6% patients during malignancy treatment. Clinical and biochemical signs of HCH were mild in most of the patients, minimal liver fibrosis (F0–1 by METAVIR system) was discovered in 47.3% patients, severe fibrosis or cirrhosis (F3–4) was diagnosed in 40% of participants. Only 20 (20.8%) of patients received antiviral therapy against HCV prior to enrollment. Regression analysis demonstrated that age >55 years old, late onset of antiviral therapy, and poor nutritional status were significant predictors of death from hematological malignancy. Survey conducted among physicians of hematological oncology hospitals in Saint-Petersburg revealed gaps in knowledge on presentation and risks of HCV infection, as well as on opportunities of modern antiviral therapy.
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##article.viewOnOriginalSite##About the authors
Mikhail S. Nozhkin
Pavlov First Saint Petersburg State Medical University
Email: dlioznov@yandex.ru
ORCID iD: 0000-0003-4828-6709
кандидат медицинских наук, ассистент кафедры инфекционных болезней и эпидемиологии
Russian Federation, Saint PetersburgDmitry A. Lioznov
Pavlov First Saint Petersburg State Medical University; Smorodintsev Research Institute of Influenza
Email: dlioznov@yandex.ru
ORCID iD: 0000-0003-3643-7354
доктор медицинских наук, доцент, зав. кафедры инфекционных болезней и эпидемиологии, директор ФГБУ «НИИ гриппа имени А.А. Смородинцева»
Russian Federation, Saint Petersburg; Saint PetersburgTamara V. Antonova
Pavlov First Saint Petersburg State Medical University
Email: dlioznov@yandex.ru
ORCID iD: 0000-0002-1784-6235
доктор медицинских наук, профессор, профессор кафедры инфекционных болезней и эпидемиологии
Russian Federation, Saint PetersburgOlga V. Gorchakova
Pavlov First Saint Petersburg State Medical University
Email: dlioznov@yandex.ru
ORCID iD: 0000-0001-5458-4329
кандидат медицинских наук, научный сотрудник лаб. хронических вирусных инфекций Научно-исследовательского центра
Russian Federation, Saint PetersburgEdward M. Goldstein
Harvard T.H. Chan School of Public Healt
Email: dlioznov@yandex.ru
ORCID iD: 0000-0002-6795-0559
кандидат физ.-мат. наук, старший научный сотрудник Гарвардской школы общественного здравоохранения
United States, BostonMarina O. Popova
Pavlov First Saint Petersburg State Medical University
Email: dlioznov@yandex.ru
ORCID iD: 0000-0001-8536-5495
кандидат медицинских наук, врач-гематолог отделения трансплантации костного мозга для взрослых Научно-исследовательского института детской онкологии, гематологии и трансплантологии имени Р.М. Горбачевой, доцент кафедры гематологии, трансфузиологии, трансплантологии с курсом детской онкологии факультета послевузовского образования имени профессор Б.В. Афанасьева
Russian Federation, Saint PetersburgTatyana V. Shneyder
Leningrad Regional Clinical Hospital
Author for correspondence.
Email: dlioznov@yandex.ru
врач-гематолог, зав. отделением онкогематологии, гл. внештатный гематолог Ленинградской области
Russian Federation, Saint PetersburgReferences
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