Clinical portrait of a patient with COVID-19. The experience of a multidisciplinary clinic

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Abstract

Aim. Evaluation of the clinical characteristics in patients with COVID-19.

Materials and methods. The article presents clinical and instrumental data of 1169 patients included in a single-center mixed study. Patients were tested for COVID-19 using polymerase chain reaction, computed tomography (CT), and antibody screening. Clinical history data were collected.

Results. In patients with confirmed COVID-19, lung damage and a positive test for antibodies were observed in 75.5 and 45.2% of cases, respectively. The most common symptoms of COVID-19 were: fever (73.2%), weakness, (72.7%) dry cough (62.8%) and shortness of breath (55.4%). Patients with CT-visualized lung lesions were more likely to have clinical symptoms and elevated levels of antibodies. Patients with chronic diseases of the endocrine system, circulatory system, and respiratory system had a more severe course of the disease (CT-1–4: 91.2–96.3%) than patients without chronic diseases (CT-1–4: 85,1%).

Conclusion. We have compiled a clinical profile of patients with COVID-19 and highlighted the most significant clinical characteristics corresponding to a more severe course of the disease. Our data showed that patients with chronic diseases require a personalized approach and the development of specific criteria for the diagnosis and treatment of COVID-19.

About the authors

Gulsara E. Baimakanova

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0001-8198-9313

д-р мед. наук, зав. отд-нием пульмонологии ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Igor E. Khatkov

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0002-4088-8118

чл.-кор. РАН, д-р мед. наук, проф., дир. ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Galina A. Dudina

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0001-9673-1067

д-р мед. наук, зав. отд-нием онкогематологии ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Anzhelika S. Chegodar

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0001-7753-3698

врач клинико-лабораторной диагностики Центра персонализированной медицины ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Konstantin A. Rumyantsev

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0003-3184-5439

канд. биол. наук, ст. науч. сотр. Центра персонализированной медицины ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Filipp S. Sviridov

Loginov Moscow Clinical Scientific and Practical Center; Bochkov Research Centre for Medical Genetics

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0003-3767-9339

мл. науч. сотр. Центра персонализированной медицины ГБУЗ «МКНЦ им. А.С. Логинова», науч. сотр. лаб. мутагенеза ФГБНУ «МГНЦ им. акад. Н.П. Бочкова»

 

Russian Federation, Moscow

Alena V. Osipova

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0001-9664-0931

мл. науч. сотр. Центра персонализированной медицины ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Anastasiia M. Danishevich

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0002-3573-8342

врач-генетик Центра персонализированной медицины ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Karina K. Noskova

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru

канд. мед. наук, зав. клинико-диагностической лаб. ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Evgeniia S. Pinashina

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0002-0223-2302

врач-ординатор ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Nataliia V. Orlova

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0002-9007-7911

зав. рентгенологическим отд-нием ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Viacheslav M. Slezinger

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0002-2049-4146

зам. глав. врача по санитарно-эпидемиологической работе ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Marina E. Chernova

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0002-6127-1723

канд. мед. наук, зав. инфекционно-эпидемиологическим отд., врач-инфекционист ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Karina A. Tovstyko

Loginov Moscow Clinical Scientific and Practical Center

Email: n.bodunova@mknc.ru
ORCID iD: 0000-0003-1989-0333

администратор Центра персонализированной медицины ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

Natalia A. Bodunova

Loginov Moscow Clinical Scientific and Practical Center

Author for correspondence.
Email: n.bodunova@mknc.ru
ORCID iD: 0000-0002-3119-7673

канд. мед. наук, зав. Центром персонализированной медицины ГБУЗ «МКНЦ им. А.С. Логинова»

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Age and sex distribution among patients.

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3. Fig. 2. Patient data distribution presented as Venn diagram. Ig – serological diagnostics was available (red). Computed tomography was available (blue). Clinical data – clinical data were available (orange).

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


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