Pathogenetic aspects of the development of cholelithiasis in patients with metabolic syndrome

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Abstract

Nowadays there is a steady tendency to increase the number of patients with gallstone disease and metabolic syndrome. Increasingly, gallstone disease is called a non-canonical cluster of metabolic syndrome, because the main components of metabolic syndrome are also modifiable risk factors for gallstone disease. This article discusses the pathogenetic parallels in the development of gallstone disease and metabolic syndrome - insulin resistance and hormones of adipose tissue, lipid metabolism disorders, immune factors and the cytokine system. There are described possible effects of cholecystectomy on metabolism in patients with metabolic syndrome.

About the authors

Yu. P. Uspenskiy

Saint Petersburg State Paediatric Medical University; Pavlov First Saint Petersburg State Medical University

Email: kyamalyok@yandex.ru
ORCID iD: 0000-0001-6434-1267

д.м.н., проф., зав. каф. факультетской терапии им. проф. В.А. Вальдмана ФГБОУ ВО СПбГПМУ, проф. каф. внутренних болезней стоматологического фак-та ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова»

Russian Federation, Saint Petersburg ; Saint Petersburg

Yu. A. Fominykh

Pavlov First Saint Petersburg State Medical University

Email: kyamalyok@yandex.ru
ORCID iD: 0000-0002-2436-3813

к.м.н., доц., доц. каф. внутренних болезней стоматологического фак-та ФГБОУ ВО «ПСПбГМУ им. акад. И.П. Павлова»

Russian Federation, Saint Petersburg

K. N. Nadzhafova

Saint Petersburg State Paediatric Medical University

Author for correspondence.
Email: kyamalyok@yandex.ru
ORCID iD: 0000-0002-8419-0272

ст. мед. лаборант каф. факультетской терапии им. проф. В.А. Вальдмана ФГБОУ ВО СПбГПМУ

Russian Federation, Saint Petersburg

A. V. Vovk

Saint Petersburg State Paediatric Medical University

Email: kyamalyok@yandex.ru
ORCID iD: 0000-0002-6550-589X

к.м.н., доц. каф. факультетской терапии им. проф. В.А. Вальдмана ФГБОУ ВО СПбГПМУ

Russian Federation, Saint Petersburg

A. V. Koshcheev

Mechnikov North-Western State Medical University

Email: kyamalyok@yandex.ru
ORCID iD: 0000-0003-1803-5298

к.м.н., ассистент каф. оперативной и клинической хирургии с топографической анатомией ФГБОУ ВО «СЗГМУ им. И.И. Мечникова»

Russian Federation, Saint Petersburg

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2. Enterohepatic circulation of fatty acids in patients with chronic calculous cholecystitis (a) and in patients after cholecystectomy (b) [29]: 1 - gallbladder-dependent enterohepatic circulation of fatty acids; 2 - gallbladder-independent enterohepatic circulation of fatty acids; 3 - intake of fatty acids into the liver through the hepatic artery; 4 - synthesis of cholic acid: cholesterol-7α-hydroxylase; 5 - synthesis of chenodeoxycholic acid: cholesterol-27-hydroxylase; 6 - The entry of fatty acids into the liver through the portal vein. PA - hepatic artery; PV - hepatic vein; BB - portal vein.

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