Dynamics of adreneractivity after transfer of myocardial infarction: annual observation
- Authors: Rebrova T.Y.1, Muslimova E.F.1, Alexandrenko V.A.1, Afanasiev S.A.1, Garganeeva A.A.1, Maksimov I.V.1
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Affiliations:
- Cardiology Research Institute, Tomsk National Research Medical Center
- Issue: Vol 93, No 1 (2021)
- Pages: 44-48
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/61887
- DOI: https://doi.org/10.26442/00403660.2021.01.200592
- ID: 61887
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Abstract
Aim. To study the change in the β-adrenergic reactivity of red blood cell membranes in patients during the first year after acute myocardial infarction.
Materials and methods. The study included 25 patients with acute myocardial infarction (AMI) who signed informed consent to participate in the study. The erythrocyte membrane β-adrenoreactivity index (β-ARM) was determined in venous blood samples upon admission to the intensive care unit, one day after admission, 6 and 12 months after the index MI was transferred using the BETA-ARM-AGAT reagent kit (Agat-Med, Russia).
Results. According to the results of dynamics assessment of β-APM during the first day, patients included in the study were divided into 2 groups. Group 1 (n=14) included patients who had an increase in β-APM in the first day, and group 2 (n=21) included patients in whom β-ARM either did not change or decreased. At the time of admission to the hospital in the formed groups, there were no differences in the β-APM index and clinical and anamnestic characteristics. A day after hospitalization, the value of β-APM in group 1 significantly exceeded the same indicator in group 2 (p=0.02). At the periods of 6 and 12 months, the β-APM indices in the groups did not differ. In the 2nd group of patients, the progression of chronic heart failure to one or more functional classes (NYHA) was significantly more often compared with the 1st group.
Conclusion. The study showed that on the first day in patients with AMI, both an increase and a decrease in the activity of the sympathoadrenal system are possible with a further leveling of these differences over the next year. For a group of patients with decreased activity of sympathoadrenal system on the first day, a more unfavorable course of heart failure in the post-infarction period is characteristic.
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##article.viewOnOriginalSite##About the authors
Tatiana Y. Rebrova
Cardiology Research Institute, Tomsk National Research Medical Center
Author for correspondence.
Email: rebrova@cardio-tomsk.ru
ORCID iD: 0000-0003-3667-9599
науч. сотр. лаб. молекулярно-клеточных патологии и генодиагностики
Russian Federation, TomskElvira F. Muslimova
Cardiology Research Institute, Tomsk National Research Medical Center
Email: rebrova@cardio-tomsk.ru
ORCID iD: 0000-0001-7361-2161
науч. сотр. лаб. молекулярно-клеточных патологии и генодиагностики
Russian Federation, TomskVictoria A. Alexandrenko
Cardiology Research Institute, Tomsk National Research Medical Center
Email: rebrova@cardio-tomsk.ru
ORCID iD: 0000-0002-6717-5898
аспирант отд-ния патологии миокарда
Russian Federation, TomskSergey A. Afanasiev
Cardiology Research Institute, Tomsk National Research Medical Center
Email: rebrova@cardio-tomsk.ru
ORCID iD: 0000-0001-6066-3998
д.м.н., проф., рук. лаб. молекулярно-клеточных патологии и генодиагностики
Russian Federation, TomskAlla A. Garganeeva
Cardiology Research Institute, Tomsk National Research Medical Center
Email: rebrova@cardio-tomsk.ru
ORCID iD: 0000-0002-9488-6900
д.м.н., проф., рук. отд-ния патологии миокарда
Russian Federation, TomskIvan V. Maksimov
Cardiology Research Institute, Tomsk National Research Medical Center
Email: rebrova@cardio-tomsk.ru
ORCID iD: 0000-0003-0367-1654
д.м.н., проф., вед. науч. сотр. отд-ния неотложной кардиологии
Russian Federation, TomskReferences
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