Tuberculosis infection in patients with inflammatory bowel diseases. Clinacal cases

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Abstract

In most cases Tuberculosis (TB) affects the lungs, but 10–15% of patients have extrapulmonary TB localisations, that is difficult to diagnose. TB is more spread among patients having the human immunodeficiency virus and among those who receive immunosuppressive therapy, specifically in patients with inflammatory bowel disease requiring long-term treatment with immunosuppressants and/or biologics. The symptoms of intestinal TB are nonspecific and may include chronic diarrhea, weight loss, fever and ascites. Differential diagnosis includes Crohn's disease, malignant neoplasms, periappendiceal abscesses, yersiniosis, etc. The article presents cases showing similarity of the intestinal form of TB with Crohn's disease, complexity dealing, diagnosing and treating patients with inflammatory bowel disease also having latent tuberculosis infection

About the authors

Maria U. Timanovskaia

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0002-7937-2346

мл. научный сотрудник отделения воспалительных заболеваний кишечника

Russian Federation, Moscow

Yuliya R. Shaykhtdinova

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0009-0005-0482-8555

мл. научный сотрудник отделения воспалительных заболеваний кишечника

Russian Federation, Moscow

Elena U. Zhulina

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0003-3479-2299

кандидат медицинских наук, научный сотрудник отделения воспалительных заболеваний кишечника

Russian Federation, Moscow

Dmitrii S. Kulakov

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0002-0855-5217

мл. научный сотрудник отделения воспалительных заболеваний кишечника

Russian Federation, Moscow

Anna V. Kagramanova

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0002-3818-6205

кандидат медицинских наук, старший научный сотрудник отделения воспалительных заболеваний кишечника

Russian Federation, Moscow

Oleg V. Knyzev

Loginov Moscow Clinical Scientific Center; Ryzhikh National Medical Research Centre for Coloproctology

Email: asfold@mail.ru
ORCID iD: 0000-0001-7250-0977

доктор медицинских наук, зав. отделением воспалительных заболеваний кишечника, профессор научно-образовательного отд.

Russian Federation, Moscow; Moscow

Asfold I. Parfenov

Loginov Moscow Clinical Scientific Center

Author for correspondence.
Email: asfold@mail.ru
ORCID iD: 0000-0002-9782-4860

доктор медицинских наук, профессор, зав. отд. патологии кишечника

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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1. JATS XML
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2. Fig. 1. CT scan of thoracic organs: Disseminated pulmonary tuberculosis in patient M. Numerous small lesions in the lungs, increased mediastinal lymph nodes.

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3. Fig. 2. Small intestine loops, covered with fibrin, parietal and visceral peritoneum, with mylar multiple whitish lesions, dense in palpation.

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4. Fig. 3. Caseous granules in the mesoileum.

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5. Fig. 4. CT scan of the thoracic organs: focal changes of the lungs with destruction in the patient O.

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