Email this article Efficacy and safety of topical combination therapy in patients with acute otitis externa
- Authors: Gurov A.V.1,2, Kriukov A.I.1,2, Shadrin G.B.1, Izotova G.N.1, Zotova P.K.1
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Affiliations:
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology
- Pirogov Russian National Research Medical University
- Issue: Vol 95, No 11 (2023)
- Pages: 937-942
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/231999
- DOI: https://doi.org/10.26442/00403660.2023.11.202455
- ID: 231999
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Abstract
Aim. To study the structure of the microbial landscape in patients with acute otitis externa, as well as to evaluate the efficacy and safety of the combined drug chloramphenicol/clotrimazole/beclomethasone/lidocaine (Candibiotic) as an empirical therapy of this disease.
Materials and methods. In this retrospective study of real clinical practice, outpatient records of 963 patients who applied to the KDO of the Sverzhevsky Research Clinical Institute of Otorhinolaryngology with symptoms of otitis externa in the period from 2017 to 2022 were selected. Additional analysis was carried out on the clinical records of patients who received the combined drug Candibiotic. The endpoints of this analysis included data on the clinical and microbiological efficacy of therapy, as well as safety information.
Results. According to microbiological testing, 60.6% of microorganisms belonged to bacterial flora, 26% were bacterial-fungal associations, 11.6% were monofungal flora, in 1.8% of cases there was no growth of microorganisms. The most frequently isolated microorganisms were: Pseudomonas spp (n=291; 29.16%), Staphylococcus spp. (n=214; 21.4%), Candida spp. (n=194; 19.4%), Aspergillus spp. (n=133; 13.3%). Most of the patients (71.0%) received Candibiotic. In 69.7% of patients, the resolution of the clinical symptoms of otitis externa occurred within 7 days of therapy with Candibiotic. Complete eradication of microorganisms occurred in 87% of cases. Adverse events were recorded only in 3 (0.04%) cases.
Conclusion. The study demonstrated an extremely high level of clinical efficacy and safety of therapy in patients with acute external infectious otitis who received the Candibiotic, which can be used as an initial empirical therapy in patients with otitis externa.
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##article.viewOnOriginalSite##About the authors
Alexander V. Gurov
Sverzhevsky Research Clinical Institute of Otorhinolaryngology; Pirogov Russian National Research Medical University
Author for correspondence.
Email: alex9999@inbox.ru
ORCID iD: 0000-0001-9811-8397
доктор медицинских наук, профессор, профессор кафедры оториноларингологии лечебного факультета, микро-биологии и вирусологии педиатрического факультета ФГАОУ ВО «РНИМУ имени Н.И. Пирогова», старший научный сотрудник отд. эпидемиологии, методологии и научного прогнозирования ГБУЗ «НИКИО имени Л.И. Свержевского»
Russian Federation, Moscow; MoscowAndrey I. Kriukov
Sverzhevsky Research Clinical Institute of Otorhinolaryngology; Pirogov Russian National Research Medical University
Email: nikio@zdrav.mos.ru
ORCID iD: 0000-0002-0149-0676
чл.-кор. РАН, доктор медицинских наук, профессор, зав. кафедры оториноларингологии имени академик Б.С. Преображенского лечебного факультета ФГАОУ ВО «РНИМУ имени Н.И. Пирогова», дир. ГБУЗ «НИКИО имени Л.И. Свержевского»
Russian Federation, Moscow; MoscowGeorgy B. Shadrin
Sverzhevsky Research Clinical Institute of Otorhinolaryngology
Email: alex9999@inbox.ru
ORCID iD: 0000-0002-3559-5302
кандидат медицинских наук, зав. консультативно-диагностическим отделением, врач-оториноларинголог консультативно-диагностического отделения №1 ГБУЗ «НИКИО имени Л.И. Свержевского»
Russian Federation, MoscowGalina N. Izotova
Sverzhevsky Research Clinical Institute of Otorhinolaryngology
Email: galina-izotova@yandex.ru
ORCID iD: 0000-0002-3134-3343
кандидат биол. наук, вед. научный сотрудник отд. эпидемиологии, методологии и научного прогнозирования ГБУЗ «НИКИО имени Л.И. Свержевского»
Russian Federation, MoscowPolina K. Zotova
Sverzhevsky Research Clinical Institute of Otorhinolaryngology
Email: alex9999@inbox.ru
ORCID iD: 0000-0001-9455-0705
врач клинического обсервационного отд. ГБУЗ «НИКИО имени Л.И. Свержевского»
Russian Federation, MoscowReferences
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