Email this article Association between cardio-ankle vascular index and markers of thrombosis in hospitalized patients COVID-19
- Authors: Podzolkov V.I.1, Bragina A.E.1, Tarzimanova A.I.1, Ogibenina E.S.1, Shvedov I.I.1, Ivannikov A.A.1, Megeneishvili N.К.1, Sutulova A.V.1
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Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 95, No 7 (2023)
- Pages: 548-553
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/148295
- DOI: https://doi.org/10.26442/00403660.2023.07.202292
- ID: 148295
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Abstract
Aim. To evaluate the relationship between the cardio-ankle vascular index (CAVI) and the marker of procoagulant state – D-dimer in hospitalized patients with coronavirus disease 2019 (COVID-19).
Materials and methods. This cross-sectional study involved adult patients admitted to the University hospital with clinically diagnosed or laboratory-confirmed COVID-19. We compared groups of patients with normal and elevated CAVI. Univariate and multivariate logistic regression analyses were performed to assess the association between risk factors and elevated D-dimer levels; odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated to determine the strength of association. A p<0.05 was considered statistically significant.
Results. The study included 152 patients [64 (42.1%) men and 88 (57.9%) women], mean age 59.10±12.74 years. 45 (29.6%) had elevated CAVI. Patients with elevated CAVI were older, had more comorbid diseases, a higher Charlson comorbidity index and D-dimer levels. Age, the comorbidity index, and CAVI above 9.5 were associated with elevated D-dimer levels in patients with COVID-19. In a multivariate logistic regression, CAVI above 9.5 was an independent predictor of increased D-dimer in patients with COVID-19 (OR 2.513, 95% CI 1.050–6.012; p=0.038).
Conclusion. In this study, for the first time, the association between a vascular stiffness marker, elevated CAVI, and increased D-dimer levels in COVID-19 patients was shown. This relationship may be a consequence of endothelial dysfunction and can be used as an additional marker of coagulopathy developing as part of COVID-19.
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##article.viewOnOriginalSite##About the authors
Valery I. Podzolkov
Sechenov First Moscow State Medical University (Sechenov University)
Email: anna.bragina@mail.ru
ORCID iD: 0000-0002-0758-5609
д-р мед. наук, проф., зав. каф. факультетской терапии №2 Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowAnna E. Bragina
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: anna.bragina@mail.ru
ORCID iD: 0000-0002-2699-1610
д-р мед. наук, проф. каф. факультетской терапии №2 Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowAida I. Tarzimanova
Sechenov First Moscow State Medical University (Sechenov University)
Email: anna.bragina@mail.ru
ORCID iD: 0000-0001-9536-8307
д-р мед. наук, проф. каф. факультетской терапии №2 Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowEkaterina S. Ogibenina
Sechenov First Moscow State Medical University (Sechenov University)
Email: anna.bragina@mail.ru
ORCID iD: 0000-0002-2129-818X
зав. отд-нием Университетской клинической больницы №4
Russian Federation, MoscowIlya I. Shvedov
Sechenov First Moscow State Medical University (Sechenov University)
Email: anna.bragina@mail.ru
ORCID iD: 0000-0001-9722-6097
аспирант каф. факультетской терапии №2 Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowAlexander A. Ivannikov
Sechenov First Moscow State Medical University (Sechenov University)
Email: anna.bragina@mail.ru
ORCID iD: 0000-0002-9738-1801
аспирант каф. факультетской терапии №2 Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowNino К. Megeneishvili
Sechenov First Moscow State Medical University (Sechenov University)
Email: anna.bragina@mail.ru
ORCID iD: 0000-0002-6667-4257
студентка Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowAngelina V. Sutulova
Sechenov First Moscow State Medical University (Sechenov University)
Email: anna.bragina@mail.ru
ORCID iD: 0000-0003-3321-0445
студентка Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowReferences
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