Risk factors of kidney injury in patients with COVID-19
- Authors: Shchepalina A.A.1, Chebotareva N.V.1, Kitbalian A.A.1,2, Potapov P.P.1,2, Nartova A.A.1, Akulkina L.A.1, Brovko M.Y.1, Sholomova V.I.1, Moiseev S.V.1,2
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Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Lomonosov Moscow State University
- Issue: Vol 94, No 6 (2022)
- Pages: 743-747
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/109613
- DOI: https://doi.org/10.26442/00403660.2022.06.201568
- ID: 109613
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Abstract
Aim. To determine the incidence and risk factors of acute kidney injury (AKI) in Russian cohort of patients with COVID-19.
Materials and methods. We included 315 patients, who were hospitalized with COVID-19 from October 2020 till February 2021. The diagnosis was established on the basis of the positive SARS-CoV-2 swab test and/or typical radiologic findings on CT scans.
Results. AKI complicated the clinical course in 92 (29.21%) cases. The independent risk factors of AKI were female sex, underline chronic kidney disease and the highest level of C-reactive protein during hospitalization. In the general group of patients were 41 (13%) lethal cases, in the group with AKI – 32 (34.8%). Compared with those without AKI, patients with AKI had 4.065 (95% confidence interval 2.154 to 7.671) times the odds of death. Respiratory support, the highest serum creatinine and glucose levels appeared to be the risk factors of death among patients with AKI in the multivariable Cox regression.
Conclusion. The clinical course of COVID-19 was complicated by AKI in 29% cases. The independent risk factors of AKI in patients with COVID-19 are underline chronic kidney disease, circulatory disorder and the highest level of C-reactive protein during hospitalization.
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##article.viewOnOriginalSite##About the authors
Anastasia A. Shchepalina
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-1826-0519
аспирант каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского
Russian Federation, MoscowNatalia V. Chebotareva
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-2128-8560
д-р мед. наук, проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-нефролог Университетской клинической больницы №3
Russian Federation, MoscowAram A. Kitbalian
Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0546-988X
врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, аспирант каф. внутренних болезней фак-та фундаментальной медицины
Russian Federation, Moscow; MoscowPavel P. Potapov
Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-4366-2832
врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, аспирант каф. внутренних болезней фак-та фундаментальной медицины
Russian Federation, Moscow; MoscowAnna A. Nartova
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0657-4446
студентка Международной школы «Медицина будущего» (ЦИОП)
Russian Federation, MoscowLarisa A. Akulkina
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-4307-8882
ассистент каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3
Russian Federation, MoscowMikhail Yu. Brovko
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0023-2701
канд. мед. наук, доц. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-пульмонолог, зам. глав. врача по медицинской части Университетской клинической больницы №3
Russian Federation, MoscowVictoria I. Sholomova
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-8785-7968
канд. мед. наук, ассистент каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, зав. отд-нием пульмонологии и профпатологии Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3
Russian Federation, MoscowSergey V. Moiseev
Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-7232-4640
акад. РАН, д-р мед. наук, проф., проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, дир. Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, проф. каф. внутренних болезней фак-та фундаментальной медицины
Russian Federation, Moscow; MoscowReferences
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