Risk factors of kidney injury in patients with COVID-19
- 作者: Shchepalina A.1, Chebotareva N.1, Kitbalian A.1,2, Potapov P.1,2, Nartova A.1, Akulkina L.1, Brovko M.1, Sholomova V.1, Moiseev S.1,2
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隶属关系:
- Sechenov First Moscow State Medical University (Sechenov University)
- Lomonosov Moscow State University
- 期: 卷 94, 编号 6 (2022)
- 页面: 743-747
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/109613
- DOI: https://doi.org/10.26442/00403660.2022.06.201568
- ID: 109613
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Aim. To determine the incidence and risk factors of acute kidney injury (AKI) in Russian cohort of patients with COVID-19.
Materials and methods. We included 315 patients, who were hospitalized with COVID-19 from October 2020 till February 2021. The diagnosis was established on the basis of the positive SARS-CoV-2 swab test and/or typical radiologic findings on CT scans.
Results. AKI complicated the clinical course in 92 (29.21%) cases. The independent risk factors of AKI were female sex, underline chronic kidney disease and the highest level of C-reactive protein during hospitalization. In the general group of patients were 41 (13%) lethal cases, in the group with AKI – 32 (34.8%). Compared with those without AKI, patients with AKI had 4.065 (95% confidence interval 2.154 to 7.671) times the odds of death. Respiratory support, the highest serum creatinine and glucose levels appeared to be the risk factors of death among patients with AKI in the multivariable Cox regression.
Conclusion. The clinical course of COVID-19 was complicated by AKI in 29% cases. The independent risk factors of AKI in patients with COVID-19 are underline chronic kidney disease, circulatory disorder and the highest level of C-reactive protein during hospitalization.
作者简介
Anastasia Shchepalina
Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-1826-0519
аспирант каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского
俄罗斯联邦, MoscowNatalia Chebotareva
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-2128-8560
д-р мед. наук, проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-нефролог Университетской клинической больницы №3
俄罗斯联邦, MoscowAram Kitbalian
Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0546-988X
врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, аспирант каф. внутренних болезней фак-та фундаментальной медицины
俄罗斯联邦, Moscow; MoscowPavel Potapov
Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-4366-2832
врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, аспирант каф. внутренних болезней фак-та фундаментальной медицины
俄罗斯联邦, Moscow; MoscowAnna Nartova
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0657-4446
студентка Международной школы «Медицина будущего» (ЦИОП)
俄罗斯联邦, MoscowLarisa Akulkina
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-4307-8882
ассистент каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3
俄罗斯联邦, MoscowMikhail Brovko
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0023-2701
канд. мед. наук, доц. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-пульмонолог, зам. глав. врача по медицинской части Университетской клинической больницы №3
俄罗斯联邦, MoscowVictoria Sholomova
Sechenov First Moscow State Medical University (Sechenov University)
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-8785-7968
канд. мед. наук, ассистент каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, зав. отд-нием пульмонологии и профпатологии Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3
俄罗斯联邦, MoscowSergey Moiseev
Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-7232-4640
акад. РАН, д-р мед. наук, проф., проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, дир. Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, проф. каф. внутренних болезней фак-та фундаментальной медицины
俄罗斯联邦, Moscow; Moscow参考
- Hu B, Guo H, Zhou P, Shi ZL. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 2021;19(3):141-54. doi: 10.1038/s41579-020-00459-7
- Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426(6965):450-4. doi: 10.1038/nature02145
- Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-74. doi: 10.1016/S0140-6736(20)30251-8
- Hirsch JS, Ng JH, Ross DW, et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int. 2020;98(1):209-18. doi: 10.1016/j.kint.2020.05.006
- Diao B, Wang C, Wang R, et al. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection. Nat Commun. 2021;12(1):2506. doi: 10.1038/s41467-021-22781-1
- Li Z, Wu M, Guo J, et al. Caution on kidney dysfunctions of 2019-nCoV patients. medRxiv. 2020. doi: 10.1101/2020.02.08.20021212
- Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. doi: 10.1001/jama.2020.1585
- Lin L, Wang X, Ren J, et al. Risk factors and prognosis for COVID-19-induced acute kidney injury: a meta-analysis. BMJ Open. 2020;10(11):e042573. doi: 10.1136/bmjopen-2020-042573
- Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int, Suppl. 2012;2(1):1-138. Available at: https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf. Accessed: 10.06.2022.
- Mohamed MMB, Lukitsch I, Torres-Ortiz AE, et al. Acute kidney injury associated with coronavirus disease 2019 in urban New Orleans. Kidney360. 2020;1(7):614-22. doi: 10.34067/KID.0002652020
- Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020;323(20):2052-9. doi: 10.1001/jama.2020.6775. Erratum in: JAMA. 2020;323(20):2098.
- Sullivan MK, Lees JS, Drake TM, et al. Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. Nephrol Dial Transplant. 2022;37(2):271-84. doi: 10.1093/ndt/gfab303
- Fang Z, Gao C, Cai Y, et al. A validation study of UCSD-Mayo risk score in predicting hospital-acquired acute kidney injury in COVID-19 patients. Ren Fail. 2021;43(1):1115-23. doi: 10.1080/0886022X.2021.1948429
- Su H, Yang M, Wan C, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020;98(1):219-27. doi: 10.1016/j.kint.2020.04.003
- Sharma P, Uppal NN, Wanchoo R, et al. COVID-19-associated kidney injury: A case series of kidney biopsy findings. J Am Soc Nephrol. 2020;31(9):1948-58. doi: 10.1681/ASN.2020050699
- Li XQ, Liu H, Meng Y, et al. Critical roles of cytokine storm and secondary bacterial infection in acute kidney injury development in COVID-19: A multi-center retrospective cohort study. J Med Virol. 2021;93(12):6641-52. doi: 10.1002/jmv.27234
- Zhou Y, Lu K, Pfefferle S. A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms. J Virol. 2010;84(17):8753-64. doi: 10.1128/JVI.00554-10
- Zucoloto AZ, Jenne CN. Platelet-neutrophil interplay: insights into neutrophil extracellular trap (NET)-driven coagulation in infection. Front Cardiovasc Med. 2019;6:85. doi: 10.3389/fcvm.2019.00085
- van den Akker JP, Egal M, Groeneveld AB. Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: a systematic review and meta‐analysis. Crit Care. 2013;17(3):R98. doi: 10.1186/cc12743
- Tram N, Chiodini B, Montesinos I, et al. Rhabdomyolysis and acute kidney injury as leading COVID-19 presentation in an adolescent. Pediatr Infect Dis J. 2020;39(10):e314-5. doi: 10.1097/INF.0000000000002853