Risk factors of kidney injury in patients with COVID-19

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Aim. To determine the incidence and risk factors of acute kidney injury (AKI) in Russian cohort of patients with COVID-19.

Materials and methods. We included 315 patients, who were hospitalized with COVID-19 from October 2020 till February 2021. The diagnosis was established on the basis of the positive SARS-CoV-2 swab test and/or typical radiologic findings on CT scans.

Results. AKI complicated the clinical course in 92 (29.21%) cases. The independent risk factors of AKI were female sex, underline chronic kidney disease and the highest level of C-reactive protein during hospitalization. In the general group of patients were 41 (13%) lethal cases, in the group with AKI – 32 (34.8%). Compared with those without AKI, patients with AKI had 4.065 (95% confidence interval 2.154 to 7.671) times the odds of death. Respiratory support, the highest serum creatinine and glucose levels appeared to be the risk factors of death among patients with AKI in the multivariable Cox regression.

Conclusion. The clinical course of COVID-19 was complicated by AKI in 29% cases. The independent risk factors of AKI in patients with COVID-19 are underline chronic kidney disease, circulatory disorder and the highest level of C-reactive protein during hospitalization.

作者简介

Anastasia Shchepalina

Sechenov First Moscow State Medical University (Sechenov University)

编辑信件的主要联系方式.
Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-1826-0519

аспирант каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского

俄罗斯联邦, Moscow

Natalia Chebotareva

Sechenov First Moscow State Medical University (Sechenov University)

Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-2128-8560

д-р мед. наук, проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-нефролог Университетской клинической больницы №3

俄罗斯联邦, Moscow

Aram Kitbalian

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0546-988X

врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, аспирант каф. внутренних болезней фак-та фундаментальной медицины

俄罗斯联邦, Moscow; Moscow

Pavel Potapov

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-4366-2832

врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, аспирант каф. внутренних болезней фак-та фундаментальной медицины

俄罗斯联邦, Moscow; Moscow

Anna Nartova

Sechenov First Moscow State Medical University (Sechenov University)

Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0657-4446

студентка Международной школы «Медицина будущего» (ЦИОП)

俄罗斯联邦, Moscow

Larisa Akulkina

Sechenov First Moscow State Medical University (Sechenov University)

Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-4307-8882

ассистент каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-пульмонолог Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3

俄罗斯联邦, Moscow

Mikhail Brovko

Sechenov First Moscow State Medical University (Sechenov University)

Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0003-0023-2701

канд. мед. наук, доц. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, врач-пульмонолог, зам. глав. врача по медицинской части Университетской клинической больницы №3

俄罗斯联邦, Moscow

Victoria Sholomova

Sechenov First Moscow State Medical University (Sechenov University)

Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-8785-7968

канд. мед. наук, ассистент каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, зав. отд-нием пульмонологии и профпатологии Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3

俄罗斯联邦, Moscow

Sergey Moiseev

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: anastasia.schepalina@yandex.ru
ORCID iD: 0000-0002-7232-4640

акад. РАН, д-р мед. наук, проф., проф. каф. внутренних, профессиональных болезней и ревматологии Института клинической медицины им. Н.В. Склифосовского, дир. Клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Университетской клинической больницы №3, проф. каф. внутренних болезней фак-та фундаментальной медицины

俄罗斯联邦, Moscow; Moscow

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