Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome

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Abstract

Aim. To evaluate the possible association of CYP2C8 gene polymorphisms with the clinical efficacy and safety of ketorolac in relation to postoperative pain.

Materials and methods. The study included 107 patients after video laparoscopic cholecystectomy, who received ketorolac (30 mg 2.0 w/m 3 r/d) as postoperative pain relief. All patients were genotyped for CYP2C8. The pain syndrome was assessed using the visual analog scale, the McGill pain questionnaire. The profile of adverse reactions was assessed by the dynamics of red blood counts, as a possible trigger for the development of gastrointestinal bleeding according to the method of global assessment of triggers (Global Trigger Tool – GTT).

Results. According to visual analog scale data: in carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080) after 12, 24, 36, 48 hours the intensity of pain syndrome is lower than in carriers of the wild type (p<0.05). According to the McGill pain questionnaire, there were no statistically significant differences in pain intensity between the two groups.

Conclusion. In carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080), the effectiveness of anesthesia with ketorolac is higher than in carriers of the wild type. Carriage of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs10509681) does not affect the risk of developing adverse reactions after ketorolac anesthesia.

About the authors

Andranik A. Muradian

Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-4367-637X

канд. мед. наук, ассистент каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Dmitry A. Sychev

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0002-4496-3680

чл.-кор. РАН, д-р мед. наук, проф., ректор ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Dmitry A. Blagovestnov

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-5724-6034

д-р мед. наук, проф., декан хирургического фак-та ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Demyan I. Petrov

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-7665-0163

канд. мед. наук, ассистент каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Dmitry S. Skukin

Sklifosovsky Research Institute of Emergency Medicine

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-0475-7441

врач-хирург хирургического отд-ния ГБУЗ «НИИ СП им. Н.В. Склифосовского»

Russian Federation, Moscow

Irina P. Epifanova

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-0892-7153

ст. лаборант каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Zhannet A. Sozaeva

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-5166-7903

мл. науч. сотр. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Anastasia A. Kachanova

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-3194-4410

мл. науч. сотр. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Natalia P. Denisenko

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-3278-5941

канд. мед. наук, зав. отд. персонализированной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Sherzod P. Abdullaev

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-9001-1499

канд. биол. наук, зав. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

Elena A. Grishina

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0002-5621-8266

д-р биол. наук, доц., дир. Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

Russian Federation, Moscow

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