Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome
- Authors: Muradian A.A.1, Sychev D.A.1, Blagovestnov D.A.1, Petrov D.I.1, Skukin D.S.2, Epifanova I.P.1, Sozaeva Z.A.1, Kachanova A.A.1, Denisenko N.P.1, Abdullaev S.P.1, Grishina E.A.1
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Affiliations:
- Russian Medical Academy of Continuous Professional Education
- Sklifosovsky Research Institute of Emergency Medicine
- Issue: Vol 94, No 5 (2022)
- Pages: 610-615
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/108776
- DOI: https://doi.org/10.26442/00403660.2022.05.201495
- ID: 108776
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Abstract
Aim. To evaluate the possible association of CYP2C8 gene polymorphisms with the clinical efficacy and safety of ketorolac in relation to postoperative pain.
Materials and methods. The study included 107 patients after video laparoscopic cholecystectomy, who received ketorolac (30 mg 2.0 w/m 3 r/d) as postoperative pain relief. All patients were genotyped for CYP2C8. The pain syndrome was assessed using the visual analog scale, the McGill pain questionnaire. The profile of adverse reactions was assessed by the dynamics of red blood counts, as a possible trigger for the development of gastrointestinal bleeding according to the method of global assessment of triggers (Global Trigger Tool – GTT).
Results. According to visual analog scale data: in carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080) after 12, 24, 36, 48 hours the intensity of pain syndrome is lower than in carriers of the wild type (p<0.05). According to the McGill pain questionnaire, there were no statistically significant differences in pain intensity between the two groups.
Conclusion. In carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080), the effectiveness of anesthesia with ketorolac is higher than in carriers of the wild type. Carriage of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs10509681) does not affect the risk of developing adverse reactions after ketorolac anesthesia.
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##article.viewOnOriginalSite##About the authors
Andranik A. Muradian
Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-4367-637X
канд. мед. наук, ассистент каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО
Russian Federation, MoscowDmitry A. Sychev
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0002-4496-3680
чл.-кор. РАН, д-р мед. наук, проф., ректор ФГБОУ ДПО РМАНПО
Russian Federation, MoscowDmitry A. Blagovestnov
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-5724-6034
д-р мед. наук, проф., декан хирургического фак-та ФГБОУ ДПО РМАНПО
Russian Federation, MoscowDemyan I. Petrov
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-7665-0163
канд. мед. наук, ассистент каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО
Russian Federation, MoscowDmitry S. Skukin
Sklifosovsky Research Institute of Emergency Medicine
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-0475-7441
врач-хирург хирургического отд-ния ГБУЗ «НИИ СП им. Н.В. Склифосовского»
Russian Federation, MoscowIrina P. Epifanova
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-0892-7153
ст. лаборант каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО
Russian Federation, MoscowZhannet A. Sozaeva
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-5166-7903
мл. науч. сотр. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО
Russian Federation, MoscowAnastasia A. Kachanova
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-3194-4410
мл. науч. сотр. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО
Russian Federation, MoscowNatalia P. Denisenko
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-3278-5941
канд. мед. наук, зав. отд. персонализированной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО
Russian Federation, MoscowSherzod P. Abdullaev
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-9001-1499
канд. биол. наук, зав. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО
Russian Federation, MoscowElena A. Grishina
Russian Medical Academy of Continuous Professional Education
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0002-5621-8266
д-р биол. наук, доц., дир. Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО
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