Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome

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Aim. To evaluate the possible association of CYP2C8 gene polymorphisms with the clinical efficacy and safety of ketorolac in relation to postoperative pain.

Materials and methods. The study included 107 patients after video laparoscopic cholecystectomy, who received ketorolac (30 mg 2.0 w/m 3 r/d) as postoperative pain relief. All patients were genotyped for CYP2C8. The pain syndrome was assessed using the visual analog scale, the McGill pain questionnaire. The profile of adverse reactions was assessed by the dynamics of red blood counts, as a possible trigger for the development of gastrointestinal bleeding according to the method of global assessment of triggers (Global Trigger Tool – GTT).

Results. According to visual analog scale data: in carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080) after 12, 24, 36, 48 hours the intensity of pain syndrome is lower than in carriers of the wild type (p<0.05). According to the McGill pain questionnaire, there were no statistically significant differences in pain intensity between the two groups.

Conclusion. In carriers of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs11572080), the effectiveness of anesthesia with ketorolac is higher than in carriers of the wild type. Carriage of the genotype CYP2C8*3 (rs10509681) and CYP2C8*3 (rs10509681) does not affect the risk of developing adverse reactions after ketorolac anesthesia.

作者简介

Andranik Muradian

Russian Medical Academy of Continuous Professional Education

编辑信件的主要联系方式.
Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-4367-637X

канд. мед. наук, ассистент каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Dmitry Sychev

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0002-4496-3680

чл.-кор. РАН, д-р мед. наук, проф., ректор ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Dmitry Blagovestnov

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-5724-6034

д-р мед. наук, проф., декан хирургического фак-та ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Demyan Petrov

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-7665-0163

канд. мед. наук, ассистент каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Dmitry Skukin

Sklifosovsky Research Institute of Emergency Medicine

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-0475-7441

врач-хирург хирургического отд-ния ГБУЗ «НИИ СП им. Н.В. Склифосовского»

俄罗斯联邦, Moscow

Irina Epifanova

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-0892-7153

ст. лаборант каф. неотложной и общей хирургии ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Zhannet Sozaeva

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-5166-7903

мл. науч. сотр. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Anastasia Kachanova

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-3194-4410

мл. науч. сотр. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Natalia Denisenko

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0003-3278-5941

канд. мед. наук, зав. отд. персонализированной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Sherzod Abdullaev

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0001-9001-1499

канд. биол. наук, зав. отд. молекулярной медицины Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

Elena Grishina

Russian Medical Academy of Continuous Professional Education

Email: andranik_muradian@mail.ru
ORCID iD: 0000-0002-5621-8266

д-р биол. наук, доц., дир. Научно-исследовательского института молекулярной и персонализированной медицины ФГБОУ ДПО РМАНПО

俄罗斯联邦, Moscow

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