Email this article Iontophoretic transport of associates based on porous Keplerate-type cluster polyoxometalate Mo72Fe30 and containing biologically active substances
- Authors: Ostroushko A.A.1, Gagarin I.D.1, Tonkushina M.O.1, Grzhegorzhevskii K.V.1, Danilova I.G.1,2, Gette I.F.1,2, Kim G.A.3
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Affiliations:
- Research Institute of Physics and Applied Mathematics
- Institute of Immunology and Physiology, Ural Branch
- Postovsky Institute of Organic Synthesis, Ural Branch
- Issue: Vol 91, No 9 (2017)
- Pages: 1811-1815
- Section: Colloid Chemistry and Electrochemistry
- URL: https://journals.rcsi.science/0036-0244/article/view/169708
- DOI: https://doi.org/10.1134/S0036024417090230
- ID: 169708
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Abstract
The possibility of iontophoretic transport through the native membranes of biologically active substances (vitamin B1 and insulin) associated with porous clusters Mo72Fe30 polyoxometalate of the Keplerate type is demonstrated for the first time in an experimental setup. The diffusion coefficient is estimated. The possibility of transferring Keplerate ions with a protective coating of biocompatible polymer polyvinylpyrrolidone is also shown.
About the authors
A. A. Ostroushko
Research Institute of Physics and Applied Mathematics
Author for correspondence.
Email: alexander.ostroushko@urfu.ru
Russian Federation, Yekaterinburg, 620002
I. D. Gagarin
Research Institute of Physics and Applied Mathematics
Email: alexander.ostroushko@urfu.ru
Russian Federation, Yekaterinburg, 620002
M. O. Tonkushina
Research Institute of Physics and Applied Mathematics
Email: alexander.ostroushko@urfu.ru
Russian Federation, Yekaterinburg, 620002
K. V. Grzhegorzhevskii
Research Institute of Physics and Applied Mathematics
Email: alexander.ostroushko@urfu.ru
Russian Federation, Yekaterinburg, 620002
I. G. Danilova
Research Institute of Physics and Applied Mathematics; Institute of Immunology and Physiology, Ural Branch
Email: alexander.ostroushko@urfu.ru
Russian Federation, Yekaterinburg, 620002; Yekaterinburg, 620049
I. F. Gette
Research Institute of Physics and Applied Mathematics; Institute of Immunology and Physiology, Ural Branch
Email: alexander.ostroushko@urfu.ru
Russian Federation, Yekaterinburg, 620002; Yekaterinburg, 620049
G. A. Kim
Postovsky Institute of Organic Synthesis, Ural Branch
Email: alexander.ostroushko@urfu.ru
Russian Federation, Yekaterinburg, 620990
