Effect of medium acidity on the thermodynamics and kinetics of the reaction of pyridoxal 5′-phosphate with isoniazid in an aqueous solution
- Authors: Gamov G.A.1, Zavalishin M.N.1, Usacheva T.R.1, Sharnin V.A.1,2
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Affiliations:
- Ivanovo State University of Chemistry and Technology
- Krestov Institute of Solution Chemistry
- Issue: Vol 91, No 5 (2017)
- Pages: 843-849
- Section: Chemical Kinetics and Catalysis
- URL: https://journals.rcsi.science/0036-0244/article/view/169459
- DOI: https://doi.org/10.1134/S0036024417050107
- ID: 169459
Cite item
Abstract
Thermodynamic characteristics of the formation of the Schiff base between isoniazid and pyridoxal 5'-phosphate in an aqueous solution at different pH values of a medium are determined by means of spectrophotometry and calorimetric titration. The process kinetics is studied spectrophotometrically, and the reaction rate constants for the formation of the imine at different acidities of a medium are determined. Biochemical aspects of the binding of pyridoxal 5'-phosphate into stable compounds are discussed.
About the authors
G. A. Gamov
Ivanovo State University of Chemistry and Technology
Author for correspondence.
Email: georgegamov38@gmail.com
Russian Federation, Ivanovo, 153000
M. N. Zavalishin
Ivanovo State University of Chemistry and Technology
Email: georgegamov38@gmail.com
Russian Federation, Ivanovo, 153000
T. R. Usacheva
Ivanovo State University of Chemistry and Technology
Email: georgegamov38@gmail.com
Russian Federation, Ivanovo, 153000
V. A. Sharnin
Ivanovo State University of Chemistry and Technology; Krestov Institute of Solution Chemistry
Email: georgegamov38@gmail.com
Russian Federation, Ivanovo, 153000; Ivanovo, 153045