Effect of medium acidity on the thermodynamics and kinetics of the reaction of pyridoxal 5′-phosphate with isoniazid in an aqueous solution
- Авторы: Gamov G.1, Zavalishin M.1, Usacheva T.1, Sharnin V.1,2
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Учреждения:
- Ivanovo State University of Chemistry and Technology
- Krestov Institute of Solution Chemistry
- Выпуск: Том 91, № 5 (2017)
- Страницы: 843-849
- Раздел: Chemical Kinetics and Catalysis
- URL: https://journals.rcsi.science/0036-0244/article/view/169459
- DOI: https://doi.org/10.1134/S0036024417050107
- ID: 169459
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Аннотация
Thermodynamic characteristics of the formation of the Schiff base between isoniazid and pyridoxal 5'-phosphate in an aqueous solution at different pH values of a medium are determined by means of spectrophotometry and calorimetric titration. The process kinetics is studied spectrophotometrically, and the reaction rate constants for the formation of the imine at different acidities of a medium are determined. Biochemical aspects of the binding of pyridoxal 5'-phosphate into stable compounds are discussed.
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Об авторах
G. Gamov
Ivanovo State University of Chemistry and Technology
Автор, ответственный за переписку.
Email: georgegamov38@gmail.com
Россия, Ivanovo, 153000
M. Zavalishin
Ivanovo State University of Chemistry and Technology
Email: georgegamov38@gmail.com
Россия, Ivanovo, 153000
T. Usacheva
Ivanovo State University of Chemistry and Technology
Email: georgegamov38@gmail.com
Россия, Ivanovo, 153000
V. Sharnin
Ivanovo State University of Chemistry and Technology; Krestov Institute of Solution Chemistry
Email: georgegamov38@gmail.com
Россия, Ivanovo, 153000; Ivanovo, 153045