Solution behavior of metoclopramide in aqueous-alcoholic solutions at 30°C

Abstract

Densities (ρ) and refractive indices (n_D) of solutions of antiemetic drug metoclopramide (4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride hydrate) in methanolwater and ethanol-water mixtures of different compositions were measured at 30°C. Apparent molar volume (φ_v) of the drug was calculated from density data and partial molar volumes (φ_v⁰) were determined from Massons relation. Concentration dependence of nD has been studied to determine refractive indices of solution at infinite dilution (n_D⁰). Results have been interpreted in terms of solute-solvent interactions.