Solution behavior of metoclopramide in aqueous-alcoholic solutions at 30°C
- Авторы: Deosarkar S.1, Sawale R.1, Tawde P.1, Kalyankar T.2
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Учреждения:
- School of Chemical Sciences
- School of Pharmacy
- Выпуск: Том 90, № 7 (2016)
- Страницы: 1362-1366
- Раздел: Physical Chemistry of Solutions
- URL: https://journals.rcsi.science/0036-0244/article/view/168440
- DOI: https://doi.org/10.1134/S0036024416070074
- ID: 168440
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Аннотация
Densities (ρ) and refractive indices (nD) of solutions of antiemetic drug metoclopramide (4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride hydrate) in methanolwater and ethanol-water mixtures of different compositions were measured at 30°C. Apparent molar volume (φv) of the drug was calculated from density data and partial molar volumes (φv0) were determined from Massons relation. Concentration dependence of nD has been studied to determine refractive indices of solution at infinite dilution (nD0). Results have been interpreted in terms of solute-solvent interactions.
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S. Deosarkar
School of Chemical Sciences
Автор, ответственный за переписку.
Email: sandeo24@yahoo.co.in
Индия, Nanded, 431606 (MS)
R. Sawale
School of Chemical Sciences
Email: sandeo24@yahoo.co.in
Индия, Nanded, 431606 (MS)
P. Tawde
School of Chemical Sciences
Email: sandeo24@yahoo.co.in
Индия, Nanded, 431606 (MS)
T. Kalyankar
School of Pharmacy
Email: sandeo24@yahoo.co.in
Индия, Nanded, 431606 (MS)