Email this article Intermolecular interactions in rifabutin–2-hydroxypropyl-β-cyclodextrin–water solutions, according to solubility data
- Authors: Anshakova A.V.1,2, Vinogradov E.V.3, Sedush N.G.4, Kurtikyan T.S.5, Zhokhov S.S.6, Polshakov V.I.6, Ermolenko Y.V.1,2, Konyukhov V.Y.2, Maksimenko O.O.1, Gelperin S.E.1
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Affiliations:
- Nanosystem LTD
- Mendeleev University of Chemical Technology
- National Research Council
- National Research Centre “Kurchatov Institute,”
- Molecular Structure Research Center
- Department of Chemistry
- Issue: Vol 90, No 5 (2016)
- Pages: 983-989
- Section: Physical Chemistry of Solutions
- URL: https://journals.rcsi.science/0036-0244/article/view/168168
- DOI: https://doi.org/10.1134/S0036024416050058
- ID: 168168
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Abstract
The formulations of rifabutin (RB) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), obtained using different preparation techniques, are studied by means of differential scanning calorimetry and molecular spectroscopy (FTIR, NMR, Raman scattering, and photon correlation light scattering). It is established that molecules of RB do not form inclusion complexes with the molecules of HP-β-CD, and an increase in the solubility of RB determined earlier is caused by the formation of weak intermolecular associates.
About the authors
A. V. Anshakova
Nanosystem LTD; Mendeleev University of Chemical Technology
Author for correspondence.
Email: anshakova_a@mail.ru
Russian Federation, Moscow, 115193; Moscow, 125047
E. V. Vinogradov
National Research Council
Email: anshakova_a@mail.ru
Canada, Ottawa, ON, K1A 0R6
N. G. Sedush
National Research Centre “Kurchatov Institute,”
Email: anshakova_a@mail.ru
Russian Federation, Moscow, 123098
T. S. Kurtikyan
Molecular Structure Research Center
Email: anshakova_a@mail.ru
Armenia, Yerevan, 0014
S. S. Zhokhov
Department of Chemistry
Email: anshakova_a@mail.ru
Russian Federation, Moscow, 119991
V. I. Polshakov
Department of Chemistry
Email: anshakova_a@mail.ru
Russian Federation, Moscow, 119991
Yu. V. Ermolenko
Nanosystem LTD; Mendeleev University of Chemical Technology
Email: anshakova_a@mail.ru
Russian Federation, Moscow, 115193; Moscow, 125047
V. Yu. Konyukhov
Mendeleev University of Chemical Technology
Email: anshakova_a@mail.ru
Russian Federation, Moscow, 125047
O. O. Maksimenko
Nanosystem LTD
Email: anshakova_a@mail.ru
Russian Federation, Moscow, 115193
S. E. Gelperin
Nanosystem LTD
Email: anshakova_a@mail.ru
Russian Federation, Moscow, 115193
