Отправить статью по E-mail Nanozyme technology at Moscow State University. Achievements and development perspectives
- Авторы: Zaitseva E.A.1, Golovin Y.I.1,2, Kost O.A.1, Nikol’skaya I.I.1, Vlasova K.Y.1, Filatova L.Y.1, Belova A.B.1, Efremenko E.N.1, Lyagin I.V.1, Aleksashkin A.D.1, Nukolova N.V.3, Majouga A.G.1,4, Kabanov A.V.1,5, Klyachko N.L.1
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Учреждения:
- Department of Chemistry
- Derzhavin Tambov State University
- Federal Medical Research Center of Psychiatry and Addictology
- National University of Science and Technology MISiS
- Eshelman School of Pharmacy
- Выпуск: Том 71, № 4 (2016)
- Страницы: 209-220
- Раздел: Article
- URL: https://journals.rcsi.science/0027-1314/article/view/163268
- DOI: https://doi.org/10.3103/S0027131416040118
- ID: 163268
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Аннотация
The work describes novel functional bionanosystems for treatment and diagnostics on the basis of proteins, enzymes, polymeric coatings, and magnetic nanoparticles developed at Lomonosov Moscow State University Laboratory for Chemical Design of Bionanomaterials in collaboration with scientists from UNC Eshelman School of Pharmacy (USA). The properties of enzymes (superoxide dismutase, catalase, organophosphate hydrolase, and lysines of bacteriophages) and other drug molecules immobilized in polymeric complexes, as well as the methods for targeted drug delivery using cell-mediated systems and magnetic nanoparticles in in vitro and in vivo operating conditions, are discussed. Physical and chemical characteristics, including data on the functional properties of the nanoformulations, are obtained. The nanoformulations developed demonstrated high potential therapeutic efficacy for the treatment of central nervous system and brain diseases, inflammations (including inflammatory diseases of the eye), cancer and infectious diseases, neurotoxic injury, and others. The possibilities of remote control biochemical reactions using a nonheating low-frequency alternating magnetic field (AMF) for the controlled release of drugs are analyzed in the review. The experimental results of the AMF effects on bionanosystems containing magnetic nanoparticles, such as changing the catalytic activities of enzymes bound to magnetic nanoparticles and ‘disordering’ of the lipid bilayer in membranes, are considered.
Об авторах
E. Zaitseva
Department of Chemistry
Автор, ответственный за переписку.
Email: ezaitseva2008@gmail.com
Россия, Moscow
Yu. Golovin
Department of Chemistry; Derzhavin Tambov State University
Email: ezaitseva2008@gmail.com
Россия, Moscow; Tambov
O. Kost
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
I. Nikol’skaya
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
K. Vlasova
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
L. Filatova
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
A. Belova
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
E. Efremenko
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
I. Lyagin
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
A. Aleksashkin
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
N. Nukolova
Federal Medical Research Center of Psychiatry and Addictology
Email: ezaitseva2008@gmail.com
Россия, Moscow
A. Majouga
Department of Chemistry; National University of Science and Technology MISiS
Email: ezaitseva2008@gmail.com
Россия, Moscow; Moscow
A. Kabanov
Department of Chemistry; Eshelman School of Pharmacy
Email: ezaitseva2008@gmail.com
Россия, Moscow; Chapel Hill
N. Klyachko
Department of Chemistry
Email: ezaitseva2008@gmail.com
Россия, Moscow
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