电邮这篇文章 Nanozyme technology at Moscow State University. Achievements and development perspectives
- 作者: Zaitseva E.A.1, Golovin Y.I.1,2, Kost O.A.1, Nikol’skaya I.I.1, Vlasova K.Y.1, Filatova L.Y.1, Belova A.B.1, Efremenko E.N.1, Lyagin I.V.1, Aleksashkin A.D.1, Nukolova N.V.3, Majouga A.G.1,4, Kabanov A.V.1,5, Klyachko N.L.1
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隶属关系:
- Department of Chemistry
- Derzhavin Tambov State University
- Federal Medical Research Center of Psychiatry and Addictology
- National University of Science and Technology MISiS
- Eshelman School of Pharmacy
- 期: 卷 71, 编号 4 (2016)
- 页面: 209-220
- 栏目: Article
- URL: https://journals.rcsi.science/0027-1314/article/view/163268
- DOI: https://doi.org/10.3103/S0027131416040118
- ID: 163268
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详细
The work describes novel functional bionanosystems for treatment and diagnostics on the basis of proteins, enzymes, polymeric coatings, and magnetic nanoparticles developed at Lomonosov Moscow State University Laboratory for Chemical Design of Bionanomaterials in collaboration with scientists from UNC Eshelman School of Pharmacy (USA). The properties of enzymes (superoxide dismutase, catalase, organophosphate hydrolase, and lysines of bacteriophages) and other drug molecules immobilized in polymeric complexes, as well as the methods for targeted drug delivery using cell-mediated systems and magnetic nanoparticles in in vitro and in vivo operating conditions, are discussed. Physical and chemical characteristics, including data on the functional properties of the nanoformulations, are obtained. The nanoformulations developed demonstrated high potential therapeutic efficacy for the treatment of central nervous system and brain diseases, inflammations (including inflammatory diseases of the eye), cancer and infectious diseases, neurotoxic injury, and others. The possibilities of remote control biochemical reactions using a nonheating low-frequency alternating magnetic field (AMF) for the controlled release of drugs are analyzed in the review. The experimental results of the AMF effects on bionanosystems containing magnetic nanoparticles, such as changing the catalytic activities of enzymes bound to magnetic nanoparticles and ‘disordering’ of the lipid bilayer in membranes, are considered.
作者简介
E. Zaitseva
Department of Chemistry
编辑信件的主要联系方式.
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
Yu. Golovin
Department of Chemistry; Derzhavin Tambov State University
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow; Tambov
O. Kost
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
I. Nikol’skaya
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
K. Vlasova
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
L. Filatova
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
A. Belova
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
E. Efremenko
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
I. Lyagin
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
A. Aleksashkin
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
N. Nukolova
Federal Medical Research Center of Psychiatry and Addictology
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
A. Majouga
Department of Chemistry; National University of Science and Technology MISiS
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow; Moscow
A. Kabanov
Department of Chemistry; Eshelman School of Pharmacy
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow; Chapel Hill
N. Klyachko
Department of Chemistry
Email: ezaitseva2008@gmail.com
俄罗斯联邦, Moscow
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