Email this article Nanozyme technology at Moscow State University. Achievements and development perspectives
- Authors: Zaitseva E.A.1, Golovin Y.I.1,2, Kost O.A.1, Nikol’skaya I.I.1, Vlasova K.Y.1, Filatova L.Y.1, Belova A.B.1, Efremenko E.N.1, Lyagin I.V.1, Aleksashkin A.D.1, Nukolova N.V.3, Majouga A.G.1,4, Kabanov A.V.1,5, Klyachko N.L.1
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Affiliations:
- Department of Chemistry
- Derzhavin Tambov State University
- Federal Medical Research Center of Psychiatry and Addictology
- National University of Science and Technology MISiS
- Eshelman School of Pharmacy
- Issue: Vol 71, No 4 (2016)
- Pages: 209-220
- Section: Article
- URL: https://journals.rcsi.science/0027-1314/article/view/163268
- DOI: https://doi.org/10.3103/S0027131416040118
- ID: 163268
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Abstract
The work describes novel functional bionanosystems for treatment and diagnostics on the basis of proteins, enzymes, polymeric coatings, and magnetic nanoparticles developed at Lomonosov Moscow State University Laboratory for Chemical Design of Bionanomaterials in collaboration with scientists from UNC Eshelman School of Pharmacy (USA). The properties of enzymes (superoxide dismutase, catalase, organophosphate hydrolase, and lysines of bacteriophages) and other drug molecules immobilized in polymeric complexes, as well as the methods for targeted drug delivery using cell-mediated systems and magnetic nanoparticles in in vitro and in vivo operating conditions, are discussed. Physical and chemical characteristics, including data on the functional properties of the nanoformulations, are obtained. The nanoformulations developed demonstrated high potential therapeutic efficacy for the treatment of central nervous system and brain diseases, inflammations (including inflammatory diseases of the eye), cancer and infectious diseases, neurotoxic injury, and others. The possibilities of remote control biochemical reactions using a nonheating low-frequency alternating magnetic field (AMF) for the controlled release of drugs are analyzed in the review. The experimental results of the AMF effects on bionanosystems containing magnetic nanoparticles, such as changing the catalytic activities of enzymes bound to magnetic nanoparticles and ‘disordering’ of the lipid bilayer in membranes, are considered.
About the authors
E. A. Zaitseva
Department of Chemistry
Author for correspondence.
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
Yu. I. Golovin
Department of Chemistry; Derzhavin Tambov State University
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow; Tambov
O. A. Kost
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
I. I. Nikol’skaya
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
K. Yu. Vlasova
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
L. Yu. Filatova
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
A. B. Belova
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
E. N. Efremenko
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
I. V. Lyagin
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
A. D. Aleksashkin
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
N. V. Nukolova
Federal Medical Research Center of Psychiatry and Addictology
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
A. G. Majouga
Department of Chemistry; National University of Science and Technology MISiS
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow; Moscow
A. V. Kabanov
Department of Chemistry; Eshelman School of Pharmacy
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow; Chapel Hill
N. L. Klyachko
Department of Chemistry
Email: ezaitseva2008@gmail.com
Russian Federation, Moscow
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