Enviar artigo por via de e-mail Synthesis and Antimicrobial Activity of Thiosulfinates, Allicin Analogues
- Autores: Puchkov V.M.1, Lyfenko A.D.1, Koval V.S.1, Revtovich S.V.1, Kulikova V.V.1, Anufrieva N.V.1, Zemskaya A.S.1, Morozova E.A.1, Solyev P.N.1
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Afiliações:
- Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
- Edição: Volume 58, Nº 6 (2024)
- Páginas: 966-974
- Seção: ПОЛУЧЕНИЕ И СТРУКТУРНО-ФУНКЦИОНАЛЬНЫЙ АНАЛИЗ ПРОТИВОМИКРОБНЫХ СРЕДСТВ
- URL: https://journals.rcsi.science/0026-8984/article/view/280782
- DOI: https://doi.org/10.31857/S0026898424060074
- EDN: https://elibrary.ru/HMWIWS
- ID: 280782
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Resumo
Diallyl thiosulfinate (allicin) effectively inhibits the growth of various microorganisms, including antibiotic-resistant strains, so it can be considered a broad-spectrum antimicrobial compound. However, its instability in the bloodstream hinders its use as a therapeutic agent. We have synthesized a number of allicin analogues, both natural and synthetic, and evaluated in vitro their antimicrobial properties against Staphylococcus aureus and Candida albicans. The synthesized compounds were shown to exhibited more pronounced antifungal activity than antibacterial one. Among the compounds obtained, synthetic di-(2,2,2-trichloroethyl) ester of 3,3'-[(thio)sulfinyl]dipropionic acid effectively inhibited the growth of both fungi and bacteria at concentrations comparable to those of known antimicrobial agents used in medical practice.
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Sobre autores
V. Puchkov
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
A. Lyfenko
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
V. Koval
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
S. Revtovich
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
V. Kulikova
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
N. Anufrieva
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
A. Zemskaya
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
E. Morozova
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
P. Solyev
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: elmorozova@yahoo.com
Rússia, Moscow, 119991
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