Changes in the Expression of Genes, Associated with Calcium Processes, in the Hippocampus of Mice under the Influence of Chronic Social Defeat Stress

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Using data from a complete transcriptome analysis, changes in the expression of genes encoding proteins involved in calcium regulation processes in the hippocampus of male mice with symptoms of depression caused by chronic social defeat stress were investigated. The expression of Cacna1g, Cacnb3, Camk1g, Camk2d, Camk2n2, Caly, Caln1, S100a16, Slc24a4 genes in the hippocampus of depressed mice was increased in relation to control, while the Cacna2d1, Cacng5, Grin2a, Calm2 gene expression was reduced. The greatest number of significant correlations between the expression of the gene Calm2, which has the highest transcriptional activity, and other differentially expressed genes was revealed. It is assumed that calcium signaling in the hippocampus of mice is disrupted under the influence of chronic social defeat stress. The involvement of the Calm2 gene and the Сamk1g, Camk2d and Camk2n2 genes in this process is discussed.

作者简介

M. Pavlova

Pavlov Institute of Physiology

编辑信件的主要联系方式.
Email: pavlova@infran.ru
Russia, 199034, St. Petersburg

D. Smagin

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: dyuzhikova@infran.ru
Russia, 630090, Novosibirsk

N. Kudryavtseva

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: dyuzhikova@infran.ru
Russia, 630090, Novosibirsk

N. Dyuzhikova

Pavlov Institute of Physiology

编辑信件的主要联系方式.
Email: dyuzhikova@infran.ru
Russia, 199034, St. Petersburg

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版权所有 © М.Б. Павлова, Д.А. Смагин, Н.Н. Кудрявцева, Н.А. Дюжикова, 2023

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