Enviar artigo por via de e-mail Drug Resistance of Different Mycobacterium tuberculosis Genotypes in the Omsk Oblast, Russia
- Autores: Vyazovaya A.1, Kostyukova I.2, Gerasimova A.1, Terentieva D.1, Pasechnik O.3, Mokrousov I.1
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Afiliações:
- St. Petersburg Pasteur Institute
- Clinical Anti-tuberculosis Dispensary
- Omsk State Medical University
- Edição: Volume 93, Nº 2 (2024)
- Páginas: 244-246
- Seção: КРАТКИЕ СООБЩЕНИЯ
- URL: https://journals.rcsi.science/0026-3656/article/view/262580
- DOI: https://doi.org/10.31857/S0026365624020275
- ID: 262580
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Resumo
A total of 397 Mycobacterium tuberculosis strains isolated from newly diagnosed patients with pulmonary tuberculosis in the Omsk region in 2019‒2020 were genotyped. The prevalence of strains of the Beijing genotype (70.8%) was established, in particular of two clusters of the modern sublineage — Central Asian/Russian (46.1%) and B0/W148 (19.1%). Strains of the ancient sublineage of the Beijing genotype were represented by clusters 1071-32 and 14717-15, totaling 4.8%. Compared with other genotypes, B0/W148 cluster and the ancient Beijing sublineage were associated with multidrug resistance (MDR): 93.4% and 94.7%, respectively (P < 0.0001). Among representatives of other genetic families (LAM, Ural, T, Haarlem), drug-sensitive strains predominated (75.0%). The circulation of MDR Beijing strains requires molecular epidemiological surveillance in view of their possible wider spread.
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Sobre autores
A. Vyazovaya
St. Petersburg Pasteur Institute
Autor responsável pela correspondência
Email: elmtree2001@mail.ru
Rússia, St. Petersburg, 197101
I. Kostyukova
Clinical Anti-tuberculosis Dispensary
Email: elmtree2001@mail.ru
Rússia, Omsk, 644058
A. Gerasimova
St. Petersburg Pasteur Institute
Email: elmtree2001@mail.ru
Rússia, St. Petersburg, 197101
D. Terentieva
St. Petersburg Pasteur Institute
Email: elmtree2001@mail.ru
Rússia, St. Petersburg, 197101
O. Pasechnik
Omsk State Medical University
Email: elmtree2001@mail.ru
Rússia, Omsk, 644099
I. Mokrousov
St. Petersburg Pasteur Institute
Email: elmtree2001@mail.ru
Rússia, St. Petersburg, 197101
Bibliografia
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