Comparative Characterization of Rat Strains (Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT, SHR, BD-IX) by Their Behavior, Hormonal Level and Antioxidant Status
- 作者: Rybnikova E.1, Vetrovoi O.1, Zenko M.1
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隶属关系:
- Pavlov Institute of Physiology
- 期: 卷 54, 编号 5 (2018)
- 页面: 374-382
- 栏目: Comparative and Ontogenic Physiology
- URL: https://journals.rcsi.science/0022-0930/article/view/159563
- DOI: https://doi.org/10.1134/S0022093018050058
- ID: 159563
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详细
The rat strains Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT (low CNS excitability threshold), SHR, BD-IX (“Biocollection of the Pavlov Institute of Physiology”) were comparatively screened for the indicators of hormonal and antioxidant status as well as behavior. In male rats, the following characteristics were evaluated: behavioral (locomotor activity, anxiety level, depressive-like behavior in the Prosolt forced swim test), hormonal (corticosterone, dehydroepiandrosterone–DHEA, thyroid-stimulating hormone–TSH, thyroxine and testosterone levels) and blood antioxidative activity. Considering our data on physiological phenotyping the above rat strains, physiological maps were created for each strain and a specific descriptive biocollection format was elaborated to represent relevant information as a publicly available online resource (http://hst5.infran.ru/biocollection/) which can be helpful in choosing an experimental object and instrumental in analyzing data obtained on certain rat strains.
作者简介
E. Rybnikova
Pavlov Institute of Physiology
编辑信件的主要联系方式.
Email: rybnikova1@rambler.ru
俄罗斯联邦, St. Petersburg
O. Vetrovoi
Pavlov Institute of Physiology
Email: rybnikova1@rambler.ru
俄罗斯联邦, St. Petersburg
M. Zenko
Pavlov Institute of Physiology
Email: rybnikova1@rambler.ru
俄罗斯联邦, St. Petersburg