Comparative Characterization of Rat Strains (Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT, SHR, BD-IX) by Their Behavior, Hormonal Level and Antioxidant Status
- Authors: Rybnikova E.A.1, Vetrovoi O.V.1, Zenko M.Y.1
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Affiliations:
- Pavlov Institute of Physiology
- Issue: Vol 54, No 5 (2018)
- Pages: 374-382
- Section: Comparative and Ontogenic Physiology
- URL: https://journals.rcsi.science/0022-0930/article/view/159563
- DOI: https://doi.org/10.1134/S0022093018050058
- ID: 159563
Cite item
Abstract
The rat strains Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT (low CNS excitability threshold), SHR, BD-IX (“Biocollection of the Pavlov Institute of Physiology”) were comparatively screened for the indicators of hormonal and antioxidant status as well as behavior. In male rats, the following characteristics were evaluated: behavioral (locomotor activity, anxiety level, depressive-like behavior in the Prosolt forced swim test), hormonal (corticosterone, dehydroepiandrosterone–DHEA, thyroid-stimulating hormone–TSH, thyroxine and testosterone levels) and blood antioxidative activity. Considering our data on physiological phenotyping the above rat strains, physiological maps were created for each strain and a specific descriptive biocollection format was elaborated to represent relevant information as a publicly available online resource (http://hst5.infran.ru/biocollection/) which can be helpful in choosing an experimental object and instrumental in analyzing data obtained on certain rat strains.
About the authors
E. A. Rybnikova
Pavlov Institute of Physiology
Author for correspondence.
Email: rybnikova1@rambler.ru
Russian Federation, St. Petersburg
O. V. Vetrovoi
Pavlov Institute of Physiology
Email: rybnikova1@rambler.ru
Russian Federation, St. Petersburg
M. Yu. Zenko
Pavlov Institute of Physiology
Email: rybnikova1@rambler.ru
Russian Federation, St. Petersburg