Comparative analysis of esterase and paraoxonase activities of different serum albumin species
- 作者: Goncharov N.1,2, Terpilovskii M.1, Shmurak V.2, Belinskaya D.1, Avdonin P.3
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隶属关系:
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- Research Institute of Hygiene
- Koltsov Institute of Developmental Biology
- 期: 卷 53, 编号 4 (2017)
- 页面: 271-281
- 栏目: Comparative and Ontogenic Biochemistry
- URL: https://journals.rcsi.science/0022-0930/article/view/159280
- DOI: https://doi.org/10.1134/S0022093017040032
- ID: 159280
如何引用文章
详细
Enzymatic activities of three types of serum albumin—rat, bovine and human—were analyzed comparatively using a mathematical model. Kinetic and equilibrium constants of carboxylesterase and paraoxonase activities of albumin in Sudlow’s sites I and II were determined. The effects of specific ligands, ibuprofen and warfarin, on enzyme kinetics in these sites were studied. Ibuprofen was found to have an inhibitory effect both on carboxylesterase and paraoxonase albumin activities, whereas warfarin specifically inhibited only carboxylesterase albumin activity.
作者简介
N. Goncharov
Sechenov Institute of Evolutionary Physiology and Biochemistry; Research Institute of Hygiene
编辑信件的主要联系方式.
Email: ngoncharov@gmail.com
俄罗斯联邦, St. Petersburg; St. Petersburg
M. Terpilovskii
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: ngoncharov@gmail.com
俄罗斯联邦, St. Petersburg
V. Shmurak
Research Institute of Hygiene
Email: ngoncharov@gmail.com
俄罗斯联邦, St. Petersburg
D. Belinskaya
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: ngoncharov@gmail.com
俄罗斯联邦, St. Petersburg
P. Avdonin
Koltsov Institute of Developmental Biology
Email: ngoncharov@gmail.com
俄罗斯联邦, Moscow